比伐卢定与替罗非班联合肝素在老年STEMI急诊PCI治疗中的疗效及安全性比较.docxVIP

比伐卢定与替罗非班联合肝素在老年STEMI急诊PCI治疗中的疗效及安全性比较 泰达国际心血管病医院300457 【摘要】目的探讨比伐卢定与替罗非班联合肝素在老年急性ST段抬高型心肌梗 死(STEMI)急诊经皮冠状动脉介入术(PCI)屮治疗效果。方法 选取2015年 10月~2013年3月我院收治STEMI行急诊PCI的老年患者60例为研究对象，采 用随机分组表将患者随机分为研究组和对照组，研究组患者给予比伐卢定辅助治 疗，对照组给予替罗非班联合肝素辅助治疗，比较两组患者术后罪犯血管(TIMI) 血流分级、2h心电图ST段回落和治疗30d内心血管事件发生率、出血并发症发 生率。结果 两组患者TIMI分级屮各级比较无明显差异，无统计学意义(P0.05)o 两组患者2h心电图ST段回落率、心血管不良事件发生率比较无统计学意义(P 0.05)；治疗30d内研究组患者出血发生率3.33%显著低于对照组20.00%,比 较有统计学意义(PV0.05)。结论比伐卢定与替罗非班联合肝素在老年STEMI 急诊PCI术屮应用可辅助提高患者临床疗效，但替罗非班联合肝素易增加患者出 血风险，比伐卢定具有更高用药安全性。 【关键词】急性ST段抬高型心肌梗死；经皮冠状动脉介入术；比伐卢定；替罗 非班；肝素 【中图分类号】R148.2【文献标识码】A【文章编号】1001-5213(2016)08-0344-02 [Abstract] Objective To investigate than Lu cutting set and tirofiban non class combined with heparin in elderly patients with acute ST segment elevation myocardial infarction (STEMI) in emergency percutaneous coronary intervention (PCI) in therapeutic effect. Methods a total of 2015 February 2016 3 mon ths in our hospital STEMI admitted to emergency PCI in elderly patients 80 cases as the object of study, using randomization table were randomly divided into study group and control group, patients in study group were given than bivalirudin adjuvant therapy, the control group was given tirofiban class combined with heparin in adjuvant treatment and were compared between the two groups of patients after myocardial infarction thrombolyt:ic therapy clinical trial (TIMI) And 2h of ST segment decline and the incidenee of bleeding. Results in the two groups of patients with TIMI grade at all levels had no sign讦icant differenee, no statistical sign讦icance (P gt; 0.05). Two groups of patients with 2H ECG ST segment resolution rate, there was no significant differenee (P gt; 0.05); Study Group of patients with postpartum hemorrhage rate of 2.50%, significantly lower than that of the control group 17.50%, compared with statistical significanee (P lt; 0.05). Conclusion compared with bivalirudin with tirofiban class combined with heparin in the elderly during emergency PCI in patients wi