病理学见习课课件：Case study inflammation.ppt

Case study Inflammation History A previously healthy 23-year-old male presented to the emergency room with a 3-day history of anorexia, nausea and abdominal pain. The pain was gradual in onset, visceral in nature and epigastric in location. Medical help was sought when antacids brought no relief and the pain localized in the right lower abdominal quadrant. History Vital signs included temperature 38 C, pulse 80 per minute and blood pressure 120/80. The patient was a well developed, mild dehydrated man in moderate abdominal distress. The pharynx was unremarkable and the chest was clear. Bowel sounds were absent. The abdomen was rigid with marked rebound tenderness in the lower quadrants. No rectal tenderness was noted. An appendectomy was performed. The gross appearance of the cut appendix (right) A normal appendix (left) as control. Comparing with both, What differences are there? Under light microscophy, there is a diffuse inflammatory infiltrates in the whole wall of appendix. Note the congestion and exudates in the serosa. Under the high power field there is a neutrophils predominant infiltrate in the lumen and mucosa of appendix. What is your diagnosis? Discussion Histological diagnostic criteria Complications The clinicopathologic correlations Why he has fever? What could be found in his blood tests?