尿路感染大肠埃希菌耐药分析.pdfVIP

尿路感染大肠埃希菌耐药分析 尿路感染大肠埃希菌耐药分析 闫 雳 ［作者单位］安徽省萧县人民医院 检验科， 235200 ［摘要］目的：探讨尿路感染中大肠埃希菌的耐药性变迁，为临床合理用药提供试验依据。方法：对 2008~2010 年度尿标本检出的 234 份大肠埃希菌进行超广谱β - 内酰胺酶（ ESBLs ）检测和药敏试验，并对 药敏结果进行分析。结果：大肠埃希菌的产酶率呈增高趋势；药敏结果显示大肠埃希菌除对亚胺培南耐药 率为 0 外，对其他常用抗菌药物均出现了不同程度的耐药性， 且 ESBLS(+)的细菌耐药率普遍高于 ESBLs(-) 细菌。结论：尿路感染的大肠埃希菌耐药现象严重，尤其是 ESBLs (+) 株，要不断加强耐药性检测，为临 床合理用药提供参考。 ［关键词］ 尿路感染；大肠埃希菌；药敏试验；超广谱β - 内酰胺酶 [ 中图分类号 ]R446.5 R378.2.1 [ 文献标识码 ] A The analysis of drug resistance of Escherichia coli in urinary tract infections Yan Li ( Department of Clinical Laboratory,Xiaoxian Peoples Hospital,Xiaoxian Anhui 235200,China) \ [Abstract]Objective:To exploring the resistance changes of the Escherichia coli (E.coli) in urinary tract infection, and provid proofs about the reasonable use of drugs in clinic.Methods ：Two hundred and thirty –foue strains of E.coli in 2008 to 2010 annual urine specimen with extended-spectrum β -lactamase (ESBLs) detection and drug susceptibility test,were detected,,and the drug susceptibility results were analyzed..Results:the rate of enzy production of E.coli showed a rising trend;the drug sensitivity test shows that the resistance exists in normal antibiotics was in different dgrees expect for Imipenem,,and the rate of medical resisitance in ESBLs(+) bacteria was higher than in ESBLs(-).Conclusions:The resistant of urinary tract infection which caused by E. coli. especially in ESBLs (+) strains, is so serious. It should be strengthen in the detections of the medical resistance ,which provide the references for the clinicl rational drug use. [Keywords] urinary tract infection; Escher