糖皮质激素鼓室给药治疗突发性聋的系统评价.docVIP

Advances in Clinical Medicine 临床医学进展，2011，1,1-5 Hsns XHfi HYPERLINK /10.12677/acm.201L11001/10.12677/acm.201L11001 Published Online June 2011 ( HYPERLINK /journal/acm//journal/acm/) Intratympanic Glucocorticoids for Sudden SensorineuralHearing Loss: A Systematic Review# Wan Du , Bin Ma , Yufen Guo 1 1,3 1 1\24 EvidcnceffitttlcH Ebplifli诫锁麻￡嗣刚也【伽旃创 LanzhouDepartment of Otolaryngology, Head and Neck Surgery, the Second Clinical Medicine College of Lanzhou University, LanzhouEmail: HYPERLINK mailto:fcibdil@163.comfcibdil@163.com Received: May 21st, 2011; revised: May 22nd, 2011; accepted: May 24th, 2011. Abstract: Objective: to assess the efficacy and safety of intratympanic glucocorticoids for sudden sen- sorineural hearing loss. Methods: we searched the Cochrane Library, PubMed, EMBASE, CBM, CNKT, and VIP databases and International Clinical Trials Registry website of World Health Organization using the key words glucocorticoids^, hearing loss^ for the literatures of English and Chinese. Randomized controlled tri? als (RCTs) of intratympanic glucocorticoids versus placebo or intratympanic glucocorticoids versus con? trolled group (oral glucocorticoid/placebo) fbr sudden sensorineural hearing loss were included. According to the Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1, we assessed the quality of the included RCTs. A meta-analysis was carried out with the Cochrane Collaboration^ software RevMan 5.0.2. Results: five RCTs which contained 285 patients were included? Meta-analysis illustrated that there was statistically significant on hearing recovery rate between the two groups (OR: 3.94, 95% CT: l?03? 15」2). Hearing of pure tone average also improved significantly with intratympanic glucocorticoids therapy at 250 HZ (p 0.05). We ibund no statistically significant on the speech reception threshold (p = 0.20). Conclusions: compared with the control group, intratympanic glucocorticoids can significantly increase the hearing recove