糖皮质激素降阶梯疗法联合夫西地酸治疗婴儿湿疹的疗.docVIP

糖皮质激素降阶梯疗法联合莫匹罗星软膏治疗婴儿湿疹临床观察 江中洪I,江玉娥2,李娟2,曾抗3 [摘要1目的探讨糖皮质激素降阶梯疗法联合莫匹罗星软音治疗婴儿湿疹的疗效及安全性。方法采用随机对照开放试 验，将入选的200例患者随机分成4纽?，每纟1150例，治疗组采用降阶梯疗法，初诊吋将糠酸莫米松乳膏和莫匹罗星软 膏分别涂于患处，1次/＜!,待皮疹改善后单用地奈徳乳膏外搽，2次/周；对照细分为A、B和C组，分别单用糠酸莫米 松乳膏、地奈徳乳膏和莫匹罗星软膏外搽患处，连用2周。于治疗第1和2周末及痊愈后1周和2周时随访，记录皮 疹变化，评价红斑、丘疹、鳞屑、瘙痒及皮损面积总积分。结果 治疗1周时，治疗纽有效率(96.00%)高于其他3纽 (A组88.00%, B组为76.00%, C组为22.00%)；治疗2周时治疗组有效率(98.00%)高于A组96.00%和B组94.00%), 但差异均无统计学意义(P均＞0.05)o痊愈1周后随访,治疗组复发率(6.25%)与A组(22.22%)、B组(23.81%)比较，差异 有统计学意义(P均＜0.05)o痊愈2周后随访,治疗组复发率(10.42%)与A组(28.89%)＞ B组(28.57%)比较，差异有统计 学意义(P均＜0.05)o结论应用糖皮质激素降阶梯疗法联合莫匹罗星软膏治疗婴儿湿疹疗效好，复发率低，且不良反应 少。 [关键词]婴儿湿疹；糖皮质激素；降阶梯疗法；糠酸莫米松乳膏；地奈徳乳膏 Clinical Observation of Glucocorticoid De-escalation Therapy Combined with Mupirocin Ointment in the Treatment of Infantile Eczema JIANG Zhong-hong1, JIANG Yu-e2, LI Juan[ ZENG Kang3 (1 .Department of Dermatology,The Affiliated Hospital of Jia-Ying university, Meizhou 514000, China： 2.Department of Pediatrics .The Affiliated Hospital of Jia-Ying university, Meizhou 514000, China； 3. Dermatology Department of Nan fang Hospital, Southern Medical University, Guangzhou 510515, China) [Abstract] Objectives To explore the efficacy and safety of glucocorticoid de-escalation therapy combined with mupirocin ointment in the treatment of infantile eczema.Methods A randomized controlled open trial was perfomied? 200 patients met the inclusion criteria were randomly divided into treatment group and control group A，B、C, each of 50 cases. De-escalation therapy was applied to the treatment group, mometasone furoate cream and mupirocin ointment were respectively applied to the lesion, once per day alternatively, and the later was maintained by desonide cream after the rash cured? Control group A,B、C were given mometasone furoate cream, desonide cream and mupirocin ointment therapy respectively once per day alternatively, and the later was mmntained after the rash cured, 2 times a week.The variations of the rash were recorded and the total scores of erythema,papule,sc