生理学教学课件：10-respiration-2.pptVIP

Formation of Oxyhemoglobin O2 + Hb HbO2 High PO2 Low PO2 (Oxyhemoglobin) (Deoxyhemoglobin) O2 with Hemoglobin to form oxyhemoglobin is an oxygenation, not an oxidation O2 released from oxyhemoglobin is a deoxygenation, not a reduction The reaction is rapid, requiring less than 0.01 second Theoretically, 1 mol Hb can combine with 4 mol O2 Hb have two forms: Tense form (T form) Relaxed form (R form). R form is 500 times ability combining with O2, then change to T form O2 + Hb HbO2 High PO2 Low PO2 Oxygen Capacity: The maximum amount of oxygen can combine with Hb per 100ml blood 1.34 ml/gHb, 15gHb/100ml blood→20ml/100ml blood Oxygen Content: Actual amount of oxygen can combine with Hb per 100 ml blood Oxygen Saturation: (Oxygen Content÷Oxygen Capacity) x100% Basic Concepts: Evaluation of Hb Combine with O2 Oxygen Dissociation Curve T: 37℃, pH: 7.4, PCO2: 40 mm Hg, Hb concentration: 15g/100ml Flattened upper portion (60~100mmHg) Steep middle portion (40~60mmHg) 3. Lower portion (15~40mmHg) P50--Affinity of Hb with O2 26.5 Factors that Affect the Oxygen Dissociation Curve [H+] CO2 Temperature 2,3,-DPG [H+] PCO2: Bohr Effect Temperature 2,3-diphosphoglycerate (2,3,-DPG) 2, 3-DPG 2, 3-DPG Analyze the curve shift under exercise why? HbO2 is red Deoxyhemoglobin is bluish dark red 5g/100ml (Cyanosis) Color of HbO2 Deoxyhemoglobin CO+Hb=HbCO is cherry red CO competes the position for O2 in Hb CO has extremely high affinity for Hb, 250 times to O2 CO inhibit the release of O2 from Hb CO Poisoning Clinical Correlate “Chronic Obstructive Pulmonary Disease” (COPD) Chronic bronchitis: is an inflammatory condition that affects one or more bronchi Emphysema: stems from an overdistension of the alveoli a loss of lung elastic recoil Chronic bronchitis Emphysema often coexist Asthma: is marked by apasmodic contractions of smooth muscle in the bronchi FEV1, FVC, FEV1/FVC TLC, FRC, RV