第八章消化系统疾病PPT课件.ppt

Pathology Department of Dalian Medical University;;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University; (1) chronic superficial gastritis (CSG) common glands in lamina propria intact, lymphocyte/plasma infiltrate in shallow mucosa ;Pathology Department of Dalian Medical University;Fundic type (type A);Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;3.肥厚性胃炎(hypertrophic gastritis) 又称 Menetrier病，原因不明 ① 病变特点为粘膜皱襞肥厚、加深 变宽似脑回状。 镜下，腺体肥 大增生，腺管延长 ② 临床：胃酸低下、低蛋白血症 ;;慢性肥厚性胃炎;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;Damaging factors;病因和发病机理 HP感染、 胃液消化作用 →胃粘膜屏障破坏 神经内分泌失调 ↓ 　　　 胃液自身消化 　　　　　　　　　 　　↓ 　　　　　　　　　　 消化性溃疡 ;正常的胃粘膜防御屏障 ①粘液-碳酸氢盐屏障 ②粘膜上皮屏障 ③丰富的粘膜血流 ;胃粘膜防御屏障损伤因素 1） HP感染： 产生尿素酶、蛋白酶、磷酸酯酶和炎 症介质（白细胞三烯、趋化因子等） 2）胃酸分泌过多 3）胃排空延缓和胆汁返流 4）药物、环境因素、遗传因素 ;损伤性因素;;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;;;;;;Pathology Department of Dalian Medical University;;正常肝小叶结构模式图;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;;Pathology Department of Dalian Medical University;Pathology Department of Dalian Medical University;肝细胞损伤机制;Pathology Department of