益气活血复方逆转自发性高血压大鼠左室肥厚的实验研究.docVIP

益气活血复方逆转自发性高血压大鼠左室肥厚的实验研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：益气活血复方逆转自发性高血压大鼠左室肥厚的实验研究 1 1 材料与方法 3 2 结果 4 3 讨论 6 文2：滋阴潜阳解毒通络饮逆转自发性高血压大鼠左室肥厚的实验研究 7 1 实验材料 7 2 实验方法 8 3 实验结果 9 4 讨论 9 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 12 正文 益气活血复方逆转自发性高血压大鼠左室肥厚的实验研究 文1：益气活血复方逆转自发性高血压大鼠左室肥厚的实验研究 Experimental Study of Effect of Yiqihuoxue Recipe on Revee Left Ventricular of Spontaneously Hyperteive Rats Abstract：ObjectiveThe research was to investigate the effects of Yiqihuoxue recipe on left ventricular in spontaneously hyperteive rats(SH) and its SH were assigned randomly into 5 groups: the control groups,the groups treated with nifedipine,the other three groups treated with different doses of YiqiHuoxue 8weektreatments, systolic blood pressure (SBP),heart weight index(HWI), left ventricular mass index(LVMI). Were measured sectio of heart tissue was stained with VanGieson method. The changes of structure and shape in the myocardial cells and volume fraction in collagen were determined by automatically quantitative morphometry; The concentration of aldosterone(ALD) and angiotein Ⅱ(AngⅡ) of plasma and myocardium with radioimmunoassay were detected. ResultsYiqihuoxue recipe restrained left ventricular and then decreased collagen contents after 8weektreatments. Yiqihuoxue recipe not only restrain the RAAS activity of plasma, but also of recipe can revee left ventricular, the effect of YiqiHuoxue recipe is better than that of nifedipine. Both decreasing blood pressure and restraining RAAS activity may be the mechanism of YiqiHuoxue recipe reveing left ventricular. Key words：YiqiHuoxue recipe; Essential hyperteion with left ventricular remodeling; Aldosterone; Angiotein Ⅱ； Hypenteion 高血压病患者约有1/3出现左室肥厚(LVH)，LVH是心血管系统疾病的一项独立危险因素［1］。心脏机械负荷过重和许多非血流动力学因素如肾素－血管紧张素－醛固酮系统 (RAAS)的刺激均可诱发 LVH。益气活血复方是在长期临床实践中发现的有一定的防治高血压 LVH作用的药物，通过实验研究我们发现，益气活血复方能够降低胞内游离钙的浓度，具有钙通道阻断剂样的作用［2］。为此，本实验以 SHR为研究对象，观察益气活血复方对高血压左室肥厚的影响，并探讨其可能的作用机理。 1 材料与方法 材料14周龄 SHR 40只，雄性，清洁级，购自