人与大鼠冠状动脉增龄变化的比较研究.docVIP

人与大鼠冠状动脉增龄变化的比较研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：人与大鼠冠状动脉增龄变化的比较研究 1 1 材料与方法 3 2 结果 3 3 讨论 4 文2：增龄对大鼠局灶性脑缺血再灌注损伤的影响临床医学 5 1 材料与方法 5 2 结 果 7 3 讨 论 8 参考文摘引言： 9 原创性声明（模板） 10 文章致谢（模板） 11 正文 人与大鼠冠状动脉增龄变化的比较研究 文1：人与大鼠冠状动脉增龄变化的比较研究 Comparative research on aging changes of coronary arteries in humanbeings and rat 【Abstract】 Objective To investigate the aging changes and species differences on the structure and caliber of the coronary arteries of human and rat．Methods Anterior interventricular branches of the left coronary arteries，derived from newborn，adult and aged human subjects，are respectively observed by light microscope，and the same samples of rats(2 months，n=3;22 months，n=3)are studied by electron microscope．Results There is obvious age-related changes in human beings．The coronary artery of newborn baby has the typical internal and external elastic membranes．The tunica intima is made of only endothelium，no subendothelial layer．In adult，the subendothelial layer is formed and thickened，the internal elastic membrane became thinner and straighter．In aged，the internal and external elastic membranes both disappeared，the subendothelial layer is evidently thickened，in which there are some smallblood vessels and local calcification can be seen occasionally．The proportio of the inner diameter to the thickness of the wall descend with aging in three groups．In rat，no matter the young or old，there is only endotheliumin the tunica intima，there are no subendothelial layer and internal elastic membranes．Therefore，no hyperplasia of the wall occu．Conclusion There are obvious differentchanges of coronary artery betweenand rat in the aging beings． 【Key words】 coronary artery;aging change;morphology;light/electorn microscope 由检索 文献 可知，近些年来在探讨高血压发病机制方面，用大鼠进行高血压和动脉硬化血管壁结构与功能改变的实验研究非常热门，然而对人和大鼠动脉增龄变化及其种属差异的研究报道甚少，并不十分清楚。为进一步了解不同年龄人冠状动脉组织结构的变化，以及管径与管壁厚度之比的年龄相关性变化，了解人与大鼠冠状动脉结构及其增龄变化的种属差异，对三组人心和两组大鼠心冠脉分支分别进行了光镜和电镜水平的观察。 1 材料与方法 人心冠脉光镜标本的制备及观测：标本选自我院解剖