药学英语药学英语 (14).pptVIP

Unit Six Biopharmaceutics 生物药剂学 Part three In defining bioavailability in these terms, it is assumed that intact drug is the therapeutically active form of the drug. This definition of bioavailability would not be valid in the case of a prodrug, whose therapeutic action normally depends on it being converted into its therapeutically active form prior to or on reaching the systemic circulation. 如此定义生物利用度是基于原形药物即为药物治疗活性形式这一假设。 这种生物利用度的定义不适用于前体药物，前体药物通常在进入体循环之前或进人体循环时转化为治疗活性形式才能发挥治疗作用。 It should also be noted that in the context of bioavailability, the term systemic circulat