药学英语药学英语 (22).pptVIP

Unit EightDrug Discovery and Natural ProductsPart four Natural Product Drug Discovery: the Traditional WayIn the traditional, rather more academic, method of drug discovery from natural products, drug targets are exposed to crude extracts, and in the case of a hit, i.e. any evidence of activity, the extract is fractionated and the active compound is isolated and identified. 在传统的、更学术化的从天然产物发现药物的方法中，一般将药物靶点加入粗提物中，如果活性测定表明存在阳性结果，则将提取物进一步细分，纯化得到活性化合物并进行鉴定。 Every step of fractionation and isolation is usually guided by bioassays, and the process is called bioassay-