芪参益气滴丸治疗2型糖尿病早期肾病的疗效研究.docVIP

·520 · GIPChinese General Practice February 2011.Vol14 No.2B · 中 医 · 中 西 医 结 合 研 究 · 芪参益气滴丸治疗2型糖尿病早期肾病的疗效研究 陈永斌，万永富 【摘要】 目的 探讨芪参益气滴丸治疗2型糖尿病早期肾病的临床疗效。方法 将93例2型糖尿病早期肾病患 者随机分为3组，每组31例。 A 组采用芪参益气滴丸+依那普利治疗， B 组单用芪参益气滴九治疗， C 组单用依那普 利治疗。观察尿微量清蛋白排泄率 (UALB) 、 血糖、血脂、血液流变学指标，比较3组患者的疗效。 结果 3组患者 治疗后UALB 较治疗前均降低，差异均有统计学意义 (P0.01)。3 组患者治疗后疗效比较，差异有统计学意义 (P 0 .05),其中A 组优于B、C 组。3组治疗前血清总胆固醇 (TC)、 三酰甘油 (TG)、 高密度脂蛋白胆固醇 (HDL-C)、 低密度脂蛋白胆固醇 (LDL-C)、 全血黏度、血浆黏度、纤维蛋白原水平比较，差异均无统计学意义 (P0.05); 但 3组治疗后上述指标比较，差异均有统计学意义 (P0.05), 其 中A 、B 组均优于 C 组 。结论 芪参益气滴丸与依那 普利均能降低2型糖尿病早期肾病患者的UALB, 但芪参益气滴丸联合依那普治疗效果优于单用芪参益气滴九或依那普 利，且芪参益气滴丸有改善血脂和血液黏度作用。 【关键词】 糖尿病肾病；芪参益气滴丸；依那普利 【中图分类号】 R587.29 【文献标识码】 A 【文章编号】1007-9572(2011)02-0520-03 Curative Effect of Qishenyiqi Drop Pills on Early Diabetic Nephropathy CHEN Yong -bin,WAN Yong -fu. Department ofMedicine,Seventh Peoples Hospital of Nanning City, Nanning 530012,China 【Abstract] Objective To discuss the curative effect of Qishenyiqi drop pills on early diabetic nephropathy(DN). Methods A total of 93 early DN patients were randomized into groups A(given Qishenyiqi drop pills and enalapril),B(given only Qishenyiqi drop pills),C(given only enalapril), 31 in each. Urinary albumin excretion rate(UALB), blood glucose, blood lipids,hemorheological indexes were observed and curative effects compared among three groups. Results UALB was sig- nificantly lower after treatment than before in 3 groups(P0.01). There was significant difference in curative effect between 3 groups after treatment(P0.05),group A better than groups B, C. No significant difference was noted in serum total choles- terol, triglyceride,high density lipoprotein cholesterol, low density lipoprotein cholesterol, whole blood viscosity,plasma vis- cosity, fibrinogen before treatment(P0.05),but there was after treatment(P0.05),groups A, B better than gro