高嘌呤饮食的2型糖尿病患者心血管并发症危险因素分析.docVIP

· 2962 · · 专 题 研 究 · 高嘌呤饮食的2型糖尿病患者心血管并发症危险因素分析 王丽君，金都，涂传发，杨宏伟，顾琴红 【摘要】 目的 探讨高嘌呤饮食的2型糖尿病 (T2DM) 患者心血管并发症的危险因素。方法 将268例高嘌 呤饮食的T2DM 患者分为T2DM 非心血管并发症组和T2DM 心血管并发症组，另选择80例体检健康者作为对照组。比 较各组血尿酸、血脂(总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白)、空腹血糖、体质指数、病程和血压的 差异，并对T2DM 心血管并发症组和T2DM 非心血管并发症组有统计学差异的指标进行Logistic 回归分析，探讨 T2DM 心血管并发症的危险因素。 结果 高嘌呤饮食的 T2DM 患者心血管并发症的发病率为53.73%(144/268)。 T2DM 心血 管并发症组、 T2DM 非心血管并发症组患者的体质指数、收缩压、舒张压、血尿酸、空腹血糖、三酰甘油及低密度脂 蛋白均显著高于对照组，差异有统计学意义 (P0.05);T2DM 心血管并发症组较非心血管并发症组血尿酸及低密度 脂蛋白水平高、收缩压高、病程长，差异有统计学意义 (P0.05)。Logistic 回归分析显示：病程、收缩压和血尿酸是 T2DM 心血管并发症的危险因素 (P0.05)。 结论 血尿酸是T2DM心血管并发症的危险因素，可能与其嘌呤代谢异 常有关，与嘌呤类饮食摄入过多无关。病程和收缩压亦是T2DM 心血管并发症的独立危险因素。 【关键词】 糖尿病，2型；饮食习惯；嘌呤类；尿酸；心血管疾病；危险因素 【中图分类号】 R587.23 【文献标识码】 A 【文章编号】1007-9572(2011)09-2962-03 R isk Factors of Cardiovascular Complications among Type 2 Diabetes Mellitus Patients on High -Purine Diet WANG Li -jun,JIN Du, TU Chuan - fa, et al. Department of Endocrinology, the First Peoples Hospital of Taizhou, Taizhou 318020,China 【Abstract] Objective To explore the risk factors of cardiovascular complications in type 2 diabetes mellitus(T2DM) patients on high purine diet. Methods A total of 268 high purine diet T2DM patients were divided into the cardiovascular compli- cation group and the non -cardiovascular complication group. Another 80 healthy subjects were enrolled as controls. Cholesterol, glycerin trilaurate,high density lipoprotein, low density lipoprotein, blood uric acid, fasting blood - glucose, body mass in- dex, course of disease and blood pressure were compared between the three groups, with logistic regression analysis performed on indices statistically different between the cardiovascular complication group and the non - cardiovascular complication group. Results The incidence rate of cardiovascular complications among T2DM patients on high purine diet is 53.73%(144/ 268).Glycerin trilaurate,blood uri