探究纳米炭应用于甲状腺癌淋巴结清扫及甲状旁腺的保护效果及预后并发症分析.docx

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探究纳米炭应用于甲状腺癌淋巴结清扫及甲状旁腺的保护效果及预后并发症分析

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【摘要】目的：研究并探讨甲狀腺癌患者应用纳米炭对淋巴结清扫与甲状旁腺的保护效果及预后并发症的影响。方法：此次研究的对象是选择本院2013年1月-2017年1月收治的甲状腺癌112例患者，将其临床资料进行回顾性分析，按照临床是否应用纳米炭分成两组，每组各56例。对照组未应用纳米炭，观察组应用纳米炭，对两组淋巴结清扫及甲状旁腺的保护效果及预后并发症情况进行比较。结果：观察组术后颈侧区与中央区淋巴结清扫所占比例分别为25.00%与28.57%均较对照组的8.93%和10.71%高，比较差异均有统计学意义（P0.05）。观察组手术后72h血清Ca2+（2.01±0.10）mmol/L与甲状旁腺素水平（20.20±3.50）pg/mL改善效果均比手术前的（2.10±0.32）mmol/L和（25.30±4.60）pg/mL、对照组的（2.30±0.28）mmol/L和（33.47±5.08）pg/mL优，比较差异均有统计学意义（P0.05）。两组预后并发症发生率分别为1.79%和3.57%，比较差异无统计学意义（P0.05）。结论：甲状腺癌患者于术中应用纳米炭有利于清扫淋巴结，保护患者甲状旁腺，且预后并发症少，具有临床推广及应用价值。

【关键词】纳米炭；甲状腺癌；淋巴结清扫；甲状旁腺

Objective:Tostudyandexploretheeffectofcarbonnanoparticlesonlymphnodedissectionandparathyroidglandprotectionandprognosisinpatientswiththyroidcancer.Methods:theobjectofthisstudywastoselect112casesofthyroidcancertreatedinourhospitalinJanuary-2017January2013.Theclinicaldatawereanalyzedretrospectively.Accordingtowhethertheclinicalapplicationofnanocarbonwaspidedintotwogroups,56casesineachgroup.Thecontrolgroupdidnotusecarbonnanoparticles,theobservationgroupwastreatedwithnanocarbon,andthetwogroupswerecomparedwiththelymphnodedissectionandparathyroidprotectioneffectandprognosiscomplications.Results:theproportionofcervicalsideandlymphnodedissectionintheobservationgroupwas25%and28.57%,respectively,comparedwith8.93%and10.71%inthecontrolgroup,andthedifferencewasstatisticallysignificant(P0.05).Theimprovementeffectof72hserum(2.01+0.10)mmol/Landparathyroidhormone(20.20+3.50)pg/mLafteroperationintheobservationgroupwerecomparedwith(2.10+0.32)mmol/Land(25.30+4.60)pg/mLbeforeoperation(25.30+4.60),and(2.30+0.28)mmol/Land(33.47+5.08)pg/mLinthecontrolgroup,andthedifferencewasstatisticallysignificant(P0.05).Theincidenceofcomplicationsinthetwogroupswas1.79%and3.57%respectively,andthedifferencewasnotstatisticallysignificant(P0.05).Conclusion:theuseofnanocarbonintheoperationofthyroidcancerisbeneficialtoclearthelymphnodes,protecttheparathyroidgland,andhavelessprognosis,whichhastheva