肝硬化患者血清总胆红素、总胆汁酸及CA199水平变化的临床意义.docx

肝硬化患者血清总胆红素、总胆汁酸及CA199水平变化的临床意义

摘要：［目的］对比不同肝功能分级（Child-pugh分级）的肝硬化患者中，胆汁代谢相关指标（血清总胆红素、总胆汁酸及癌胚抗原199）水平的变化，进一步探究其临床意义。［方法］回顾性分析2021年01月至2022年06月在我院完成治疗和随访的肝硬化患者80例，作为观察组，并依据Child-pugh分级标准，将其分为Child-pughＡ级20例、Child-pughB级30例及Child-pughC级30例；选择同期于我院就诊并完成治疗与随访的非肝硬化患者40例，作为对照组。检测所有入选者血清总胆红素、总胆汁酸及CA199的水平并进行比较，进一步分析三者之间的相关性及其各自与肝硬化病变程度之间的相关性。［结果］（1）肝硬化组患者血清总胆红素、总胆汁酸及CA199水平均高于对照组（P＜0.05）；且Child-pughC级、Child-pughB级患者三个指标水平均高于Child-pughA级患者（P＜0.05）；Child-pughC级患者三个指标水平高于Child-pughB级患者（P＜0.05）。（2）三个指标之间两两呈正相关，且其与肝硬化Child-pugh分级之间也呈正相关。［结论］肝硬化患者血清总胆红素、总胆汁酸及CA199水平均高于对照组，且其水平随着肝硬化进展而逐渐升高，即其与肝功能损害程度密切相关，今后有望用于指导临床上肝硬化患者早期肝功能评估与治疗计划的制定。

关键词：肝硬化；Child-pugh分级；总胆红素；总胆汁酸；CA199

Clinicalsignificanceofserumtotalbilirubin,totalbileacidandCA199levelsinpatientswithlivercirrhosis

NIYa-Hui(DepartmentofGastroenterology,ShanxiBethuneHospital,ShanXiAcademyofMedicalSciences,TongjiShanxiHospital,ThirdHospitalofShanxiMedicalUniversity,Taiyuan,030032,China)

Abstract：[Objective]Toexplorethelevelsofserumbilemetabolismrelatedindicators(serumtotalbilirubin、totalbileacidandCA199)levelsinpatientswithlivercirrhosisandfurtherexploreitsclinicalsignificance.[Methods]EightypatientswithlivercirrhosisdiagnosedinourhospitalwereselectedasexperimentalsubjectsfromJanuary2021toJune2022retrospectively,andaccordingtotheChild-pughclassificationcriteria,eightypatientsweredividedintoChild-pughclassA（n=20）,Child-pughclassB（n=30）,andChild-pughclassC(n=30).Meanwhile,fortypatientswithnormolliverfunctionwhocompletedtreatmentandfollowed-upinourhospitalatthesametimewereselectedasthecontrolgroup.ThelevelsofserumTBil、TBAandCA199weremeasuredandcomparedinallpatients.PearsoncorrelationmethodwasusedtoanalyzethecorrelationbetweenserumTBil、TBA、CA199levelsandwiththelivercirrhosislesion.[Results](1)TheserumlevelsofTBil、TBAandCA199intheobservationgroupwerehigherth