NS-9283-d4-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

NS9283-d4

Cat.No.:HY-110168S

分⼦式:C₁₄H₄D₄N₄O

分⼦量:252.26

作⽤靶点:Isotope-LabeledCompounds;nAChR

作⽤通路:Others;MembraneTransporter/IonChannel;Neuronal

Signaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NS9283-d4是NS9283(HY-110168)的氘代物。NS9283是(α4)3(β2)2烟碱型ACh受体的正向变构调节剂

。NS9283可⽤于⼀系列神经系统疾病的研究，如注意⼒缺陷多动障碍(ADHD)、精神分裂症、帕⾦森病和阿

尔茨海默病[1]。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].MGrupe,etal.UnravellingthemechanismofactionofNS9283,apositiveallostericmodulatorof(α4)(β2)nicotinicAChreceptors.BrJ

3