NSC-663284-Standard-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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NSC663284(Standard)

Cat.No.:HY-100034R

CASNo.:383907-43-5

分⼦式:C₁₅H₁₆ClN₃O₃

分⼦量:321.76

作⽤靶点:Phosphatase;ReferenceStandards;Histone

Methyltransferase

作⽤通路:MetabolicEnzyme/Protease;Others;Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NSC663284(Standard)是NSC663284(HY-100034)的分析标准品。本产品⽤于研究及分析应⽤。NSC

663284(DA-3003-1)是⼀种有效的，细胞可渗透的且不可逆的Cdc25dualspecificityphosphatase抑制剂，

Cdc25B2的IC50为0.21μM。NSC663284表现出与Cdc25A，Cdc25B2和Cd

IC50TargetIC50:0.21μM(Cdc25B2)[1]

REFERENCES

[1].LazoJS,etal.DiscoveryandbiologicalevaluationofanewfamilyofpotentinhibitorsofthedualspecificityproteinphosphataseCdc25.

JMedChem.2001Nov22;44(24):4042-9.

[2].GuoJ,etal.PharmacologyandantitumoractivityofaquinolinedioneCdc25phosphataseinhibitorDA3003-1(NSC663284).Anticancer

Res.2007Sep-Oct;27(5A):3067-73.

[3].CoussensNP,etal.High-throughputscreeningwithnucleosomesubs