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NSC104999

Cat.No.:HY-180480

CASNo.:1118745-14-4

分⼦式:C₃₆H₄₂N₈O₄

分⼦量:650.77

作⽤靶点:EGFR

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NSC104999是⼀种与Grb7SH2结构域结合的化合物，具有中等亲和⼒(Kd=32.3μM)。NSC104999对乳腺

癌具有抗癌活性[1]。

IC50TargetKd=32.3μM(Grb7SH2domain)[1]

REFERENCES

[1].AmbayeND,etal.ThediscoveryofphenylbenzamidederivativesasGrb7-basedantitumoragents.ChemMedChem.2013

Feb;8(2):280-8.

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