Nutlin-3a-Standard-生命科学试剂-MCE.pdfVIP

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Nutlin-3a(Standard)

Cat.No.:HY-10029R

CASNo.:675576-98-4

分⼦式:C₃₀H₃₀Cl₂N₄O₄

分⼦量:581.49

作⽤靶点:MDM-2/p53;ReferenceStandards;E1/E2/E3Enzyme;

Autophagy;Apoptosis

作⽤通路:Apoptosis;Others;MetabolicEnzyme/Protease;Autophagy

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Nutlin-3a(Standard)是Nutlin-3a(HY-10029)的分析标准品。本产品⽤于研究及分析应⽤。Nutlin-3a

(Rebemadlin)是Nutlin-3的活性对映体，是⼀种有效的MDM2抑制剂。Nutlin-3a可抑制MDM2-p53相互作

⽤，稳定p53蛋⽩，从⽽诱导细胞⾃噬(autophagy)和凋亡(apoptosis)。Nutlin-3a有潜⼒⽤于TP53野⽣型

IC50TargetMDM2-p53[1]

REFERENCES

[1].CraneEK,etal.Nutlin-3a:APotentialTherapeuticOpportunityforTP53Wild-TypeOvarianCarcinomas.PLoSOne.2015Aug

6;10(8):e0135101.

[2].TovarC,etal.Small-moleculeMDM2antagonistsrevealaberrantp53signalingincancer:implicationsfortherapy.ProcNatlAcadSciU

SA.2006Feb7;103(6):1888-93.

[3].MUlrich,etal.Murinetumormodelsfortheinvivoevaluationofnaturalcompoundsan