NRL-1049-dihydrochloride-BA-1049-生命科学试剂-MCE.pdfVIP

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NRL-1049dihydrochloride

Cat.No.:HY-126432

CASNo.:1973494-17-5

Synonyms:BA-1049

分⼦式:C₁₆H₂₃Cl₂N₃O₂S

分⼦量:392.34

作⽤靶点:ROCK

作⽤通路:CellCycle/DNADamage;Cytoskeleton;StemCell/Wnt;TGF-

beta/Smad

储存⽅式:4°C,sealedstorage,awayfrommoisture

*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)

BIOLOGICALACTIVITY

⽣物活性NRL-1049dihydrochloride(BA-1049)是⼀种选择性且具有⼝服活性的Rho相关蛋⽩激酶2(ROCK2)抑制剂

，其IC50值为0.59μM。NRL-1049dihydrochloride对ROCK2的选择性是ROCK1的44倍(IC50值为26μ

M)。NRL-1049dihydrochloride可在急性损伤后保护⾎脑屏障[1]。

REFERENCES

[1].MulderIA,etal.ThenovelROCK2selectiveinhibitorNRL-1049preservestheblood-brainbarrierafteracuteinjury.JCerebBloodFlow

Metab.2024Nov;44(11):1238-1252.

McePdfHeight

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