NSC-228155-Standard-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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NSC228155(Standard)

Cat.No.:HY-101084R

CASNo.:113104-25-9

分⼦式:C₁₁H₆N₄O₄S

分⼦量:290.25

作⽤靶点:EGFR;ReferenceStandards;HistoneAcetyltransferase;

EpigeneticReaderDomain

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK;Others;

Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NSC228155(Standard)是NSC228155(HY-101084)的分析标准品。本产品⽤于研究及分析应⽤。NSC

228155为EGFR激活剂，可与EGFR的胞外区域结合，诱导EGFR的磷酸化[1]。NSC228155是⼀种有效的

KIX-KID相互作⽤抑制剂，能够抑制CREB的激酶诱导结构域(KID)和KIX(KID相互作⽤结构域，来⾃CBP

IC50TargetIC50:0.36μM(KIX-KID)[1]

REFERENCES

[1].SakanyanV,etal.ActivationofEGFRbysmallcompoundsthroughcouplingthegenerationofhydrogenperoxidetostabledimerization

ofCu/ZnSOD1.SciRep.2016Feb17;6:21088.

[2].XieF,etal.Identification,synthesisandevaluationofsubstitutedbenzofurazansasinhibitorsofCREB-mediatedgenetranscription.

BioorgMedChemLett.2013Oct1;23(19):5371-5.

Mce