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NSC781406(Standard)

Cat.No.:HY-100470R

CASNo.:1676893-24-5

分⼦式:C₂₉H₂₇F₂N₅O₅S₂

分⼦量:627.68

作⽤靶点:PI3K;ReferenceStandards;mTOR

作⽤通路:PI3K/Akt/mTOR;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NSC781406(Standard)是NSC781406(HY-100470)的分析标准品。本产品⽤于研究及分析应⽤。NSC781406

是⾼效的PI3K和mTOR抑制剂，对PI3Kα的IC50值为2nM。

IC50TargetIC50:2nM(PI3Kα),1.78μM(A549cell),0.93μM(HCT116cells),1.44μM(MDA-MB-231cells),20nM

(BEL-7404cells)[1]

REFERENCES

[1].ChenY,etal.DiscoveryofbenzenesulfonamidederivativesaspotentPI3K/mTORdualinhibitorswithinvivoefficaciesagainst

hepatocellularcarcinoma.BioorgMedChem.2016Mar1;24(5):957-66.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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