大学英语 阅读材料Nanowire-Based Biosensors.pdfVIP

NANOWIRE-BASED

BIOSENSORS

FernandoPatolsky

GengfengZheng

CharlesM.Lieber

HARVARDUNIVERSITY

Devicesbasedon

nanowiresare

emergingasapow-

etectionandquantificationofbiologicalandchem-andoptical-baseddetectionof

icalspeciesarecriticaltomanyareasofhealthcareerfulplatformforbiologicalspecies(13,14).

andthelifesciences,fromdiagnosingdiseasetotheThecombinationoftunable

thedirectdetection

discoveryandscreeningofnewdrugmolecules.conductingpropertiesofsemi-

CentraltodetectionisthetransductionofasignalofbiologicalandconductingNWs(16–20)and

associatedwiththeselectiverecognitionofaspeciestheabilitytobindanalyteson

ofinterest.Severalapproacheshavebeenreportedchemicalspecies,theirsurfaceyieldsdirect,

DD

forthedetectionofbiologicalmolecules,includingELISAs(1),label-freeelectricalreadout,

includinglowcon-

surfaceplasmonresonance(SPR;2),nanoparticles(3),chemi-whichisexceptionallyattrac-

callysensitivefield-effecttransistors(CHEMFETs;4,5),micro-centrationsofpro-tiveformanyapp