异基因造血干细胞移植早期特发性肺炎综合征多因素分析.pdfVIP

(IPS) 1997 4 2006 12 167 13 Logistic HLA (aGVHD)aGVHD aGVHDaGVHD aGVHD P 0.1 Logistic IPS 167 19 IPS (11.4%), IPS 83 (32~120 ) IPS 9 (3~92 )18 (94.7%) 18 aGVHD (94.7%) aGVHD 15 (83.3%)6 IPS HLA aGVHD~ aGVHD aGVHD~ aGVHD aGVHD IPS ~aGVHD aGVHD IPS IPS aGVHD aGVHD I Logistic II Abstract Objective: To investigate the incidence, diagnosis, clinical course and risk factors of Idiopathic Pneumonia Syndrome (IPS) following allogeneic hematopoietic stem cell transplantation ( allo-HSCT ), and explore the possible pathogenesis. Method: We retrospectively analyzed 19 cases of IPS from 167 patients undergoing allo-HSCT from April, 1997 to December, 2006. The 13 clinical parameters were selected for Logistic univariate analysis: age, sex, underlying diagnosis, disease status at transplant, transplant type, condition regimens, donor type, presence or absence of aGVHD, severity of aGVHD, HLA disparity, aGVHD of skin, liver and gut to identify risk factors for the development of IPS. Factors that were significant at the 0.1 level on univariate analysis were evaluated by multivariate analysis using a Logistic regression. The study also involved the assessment of clinical manifestation and diagnosis of IPS, and the discussion of the possible pathogenesis. Results: 19 of 167 patients developed IPS (11.4%). Median time to IPS onset after allo-HSCT was