壳聚糖基可吸收性材料的制备.docVIP

壳聚糖基可吸收性材料的制备 及作为快速止血材料的应用研究* 张勇1，陈煜2**，杨新林1，孟薇薇1，谭惠民2，李杰2，蒋建新3，侯淦泉3 （1 北京理工大学生命科学与技术学院 北京 100081；2 北京理工大学材料科学与工程学院 北京100081；3 第三军医大学创伤、烧伤复合伤国家重点实验室 重庆400042） 通过壳聚糖的水溶性衍生物羧甲基壳聚糖的接枝共聚反应，制备了新型壳聚糖基可吸收材料（Ab-CTS）。采用FT-IR对产物的结构进行了表征，采用TG对产物的热稳定性进行了研究。考察了反应条件，电解质溶液的类型，电解质溶液的浓度，溶液的pH值等对所制备的材料吸收液体性能的影响。 对该可吸收性材料应用于动脉大出血的快速止血材料领域进行了初步探索，对其止血性能和生物相容性进行了研究。建立了新西兰白兔耳创面（包含耳动脉）、股动脉、脾脏的止血实验动物模型，发现壳聚糖基可吸收性材料能牢固地粘附于出血部位，表现出良好的止血性能，其止血时间明显短于对照组（P0.05）（结果如表1～fast hemostatic fields Zhangyong1, Chenyu2, Yangxinlin1, Mengweiwei1, Tanhuimin2, Lijie2, Jiangjianxin3，Houganquan3 (1Beijing Institute of Technology, School of Life Science Technology, Beijing 100081; 2 Beijing Institute of Technology, School of Material Science Engineering, Beijing 100081; 3State Key Laboratory of Trauma Burns and Combined Injury, The Third Military Medical University, Chongqing 400042） AbstractThe absorbable chitosan material was prepared through graft copolymerized reaction of carboxymethyl chitosan . The structure of the product was characterized through FT-IR, The thermal stability of product was studied by means of TG, The relations of imbitition ability and condition of reaction, the type and concentration of electrolytic solution and pH of the solution were studied. This thesis aims to apply absorbable chitosan material to fast hemostatic fields and study primarily on its hemostatic properties and biocompatibility. The hemostatic models of ear artery, femoral artery, spleen of New Zealand rabbits were applied to study the hemostatic properties of the absorbable chitosan material. We find that this material could be hard adhered to the wound and have a good hemostatic properties, The hemostatic time for the absorbable chitosan material was short of the control groups (P0.05). Moreover, after usage this material, the wound’s surface recovers well. The biocompatibilities of the absorbable chitosan material were studied through the skin stimulation test and acute systemic toxicity test. We find this materia