沙丁胺醇、异丙托溴铵和布地奈德吸入佐治毛细支气管炎疗效分析.DOCVIP

临床医学论文-沙丁胺醇、异丙托溴铵和布地奈德吸入佐治毛细支气管炎疗效分析 ????????????????? 作者：阮仙利，王英华，梁国安，罗菁，卢洪萍 【摘要】? 目的：观察沙丁胺醇、异丙托溴铵和布地奈德联合吸入佐治毛细支气管炎的疗效。方法：将95例毛细支气管炎患儿随机分为两组，对照组95例在常规治疗基础上加用沙丁胺醇，治疗组95例在常规治疗基础上加用沙丁胺醇、异丙托溴铵、布地奈德，均2次/d空气压缩雾化泵吸入，观察两组临床症状、体征改善情况。结果：治疗组治疗后咳嗽、喘憋、湿啰音消失时间均缩短（P0.01），治疗组明显优于对照组；两组总有效率分别为93.7%和82.1%，治疗组明显优于对照组（χ2=5.3，P0.05）。结论：沙丁胺醇、异丙托溴铵和布地奈德联合雾化吸入佐治毛细支气管炎疗效满意。 【关键词】? 毛细支气管炎；沙丁胺醇；异丙托溴胺；布地奈德；吸入 ??? ［Abstract］ Objective:To observe effect of inhaled salbutamol, ipratropium bromide and budesonide in treatment of bronchiolitis. Methods:190 children with bronchiolitis were divided into two groups randomly. 95 cases in the control group were treated with salbutamol based on the routine treatment. 95 cases in the other group were treated with inhaled sabutamol, ipratropium bromide and budesonide based on the routine treatment, twice a day. Then we observed the improvement of clinical symptoms and signs. Results:The clinical effect of the treatment group was better than that of the control group in the time of disappearing of cough, asthma and moist rales (P0.01). The total effective rates of the two groups were 93.7% and 82.1% respectively, and the treatment group was significantly better than the control group (χ2=5.3,P0.05). Conclusions:The clinical result of inhaled salbutamol, ipratropium bromide and budesonide in treatment of bronchiolitis was satisfactory. ??? ［Key words］ Bronchiolitis; Salbutamol; Ipratropium bromide; Budesonide; Inhale ??? 毛细支气管炎是婴幼儿时期常见的下呼吸道感染性疾病，多见于2岁以下的婴幼儿，多数为6个月以内的小婴儿，其临床症状类似肺炎，但喘憋更为突出，至今对毛细支气管炎仍然没有令人满意的特效治疗方法。我院收治的190例毛细支气管炎患儿应用沙丁胺醇、异丙托溴铵和布地奈德联合雾化吸入疗效满意，现报告如下。 ??? 1? 资料和方法 ??? 1.1? 一般资料 ??? 190例毛细支气管炎患儿均来源于我院2006年11月～2007年4月收治的符合毛细支气管炎诊断标准［1］的住院患儿。起病均在3 d之内，采用直接免疫荧光法检测呼吸道诱导痰中脱落纤毛柱状上皮细胞中的呼吸道合胞病毒呈阳性，除外并发呼吸衰竭、心力衰竭等并发症，排除先天性心脏病、结核病、支气管异物、支气管肺发育不良等疾病。采用随机数字表法分为两组，治疗组95例，其中男63例，女32例；对照组95例，其中男65例，女30例；两组年龄均在1～6月之间，对照组平均年龄(4.4±1.2)月，治疗组平均年龄(4.2±1.1)月。两组病情、体重、性别、喂养史方面比较差异无统计学意义（P0.05），具有可比性。 ??? 1.2? 方法 ??? 两组均给予相同的抗感染、抗病毒、吸氧、止咳等对症支持治疗。治疗组给予异丙托溴铵（爱全乐，阿斯利康公司）0.5