仙灵骨葆联合密盖息治疗老年性骨质疏松症的疗效观察.docVIP

成都中医药大学硕士学位论文 中文摘要 目的：探讨运用仙灵骨葆胶囊联合密盖息治疗老年性骨质疏松症的 临床疗效及其安全性。 方法：采用随机对照试验设计，将临床确诊的老年性骨质疏松症患 者92例分为研究组46例和对照组46例，2组均每日常规口服钙剂（钙 尔奇D、迪巧等）。对照组使用密密盖息肌注，研究组在上述治疗基 础上加服仙灵骨葆胶囊。用药8周后评定2组骨痛程度及相关检测指 标的变化，并详细记录不良反应发生的情况。 结果：研究组与对照组治疗老年性骨质疏松症的总有效率分别为 93.18 ％ 和 95.65 ％ (PO.05) ， 不 良 反 应 发 生 率 为 13.04% 和 32.61%(P0.05）；治疗前后，疼痛强度两组自身比较(P0.05），治 疗 后 组 间 比 较 (PO.05) ； 两 组 治 疗 后 骨 密 度 的 改 善 程 度 比 较 (P0.05）。 结论：中西医结合治疗老年性骨质疏松症所致的骨痛疗效确切，能 有效缓解骨质疏松性腰背疼痛，并可提高患者的骨密度，有利于改 善老年人的生活质量，且不良反应少，是一种安全而有效的方法。  关键词  老年性骨质疏松症；仙灵骨葆胶囊；密盖息；中西医结合 2 成都中医药大学硕士学位论文 ABSTRACT Objective: To evaluate the efficacy and safety of Xianlinggubao capsule plus Miacalcic for Senile Osteoporosis. Methods: Under the random and contrast research method, 92 cases were involved in this trial and divided randomly into two groups (Research group and Control group): the research group(n=46) were treated by xianlinggubao capsule and salmon of calcitonin injection, while the control group(n=46) were treated only by the salmon of calcitonin injection. All the patients received the calcium(Caltrate D, D-Cal and so on) orally in equal quantity. After the treatment for 8 weeks, the nature and degree of ostealgia in all the patients were assessed，and the related outcome indexes were measured and the adverse drug reactions were recorded in detail. Results: There were no significant differences between the research group and the control group in total effective rates(95.65% for research group vs. 93.18% for control group, P0.05), While significant differences were noted across the 2 groups in the incidences of adverse drug reactions(13.04% and 32.61%, respectively, P0.05); There was no significant differences in the degree of pain remission after the treatment(P0.05), However, Both research group and control group were decreased significantly in the degrees of ostealgia after treating(P0.05). Compared with the control group, the bone density were increased significantly in the research group after treating(P0.05). Conclusions: The tre