语义判断中选择与抑制机制功能MRI的研究.pdfVIP

维普资讯 中国医学影像技术 2004年第 2O卷第2期 ChinJMedImagingTechnol，2004，Vol20，No2 · 223 · FunctionalM RIstudiesoftheneuralm echanism sofselection andinhibitioninChinesesemanticjudgement HA0Jing，LjKun—cheng，WANG Yan，CHEN Qi，PENGXiao-zhe，ZHOUXiad-lin (DepartmentofRadiology，XuanwuHospital，CapitalUniversityof MedicalSciences， Beijing100053，C^ina) [Abstract] Objective ToidentifytheneuralmechanismsofselectionandinhibitionintheChinesesemanticjudgementwith event-relatedfunctionalM RI(ER fMRI)．M ethods Ninerlght-handedhealthyadultsparticipatedintheexperimentdesigned withflankertaskandChinesesemanticjudgementtask．ThefMRIdatawerecollectedon1．5TMRIsystemsandanalyzedby AFNItogeneratetheactivationmaps．Results ①ThefunctionallocalizationsoftheselectionofsemantictaskincludedBA 6 areaintherightsuperiorfrontalgyrus，righteingulateogyrus，leftm iddlefrontalgyrus(BA 9area)，bilateralmotorareasand premotorareasandleftinferiorparietallobule．②ActivationwithintherightmiddlefrontalgyrusandleftinferiorfrontalgY— ruswasmainlycorrelatedwiththeabilitytoresolveinterferenceefficiently．Asdifficultyofthetask increased，theanterior cingulatedcortex (ACC)wasengaged．Andtheactivatedmappingtransformedfrom therighthem ispheretOtheleft．Conclu· sion ER—fMRIisavaluabletechniqueinestablishingtheneuralmechanismsofhigher-levelcognitiveprocess．Itcanmapthe functional1ocalizationsoftheselectionandinhibitionofChinesesemantic udv；~ment． [Keywords] Semanticjudgement；Flankertask；Magneticresonanceimaging．functional；Cerebral 语义判断中选择与抑制机制的功能 MRI研究 郝 晶 ，李坤成 ，王 岩。，陈 骐。，彭晓哲。，周晓林 (1．首都医科大学宣武 医院医学影像学部放射科 ，北京 100053； 2．北京大学脑科学与认知科学 中心 北京大学心理学系) [摘 要] 目的 采用事件相关功能磁共