多组分、多靶点中药整体药代动力学的研究思考与探索.pdfVIP

270 药学学报 Acta Pharmaceutica Sinica 2009, 44 (3) : 270275 多组分、多靶点中药整体药代动力学研究的思考与探索 * 湳 郝海平, 郑超 , 王广基 (中国药科大学药代动力学重点实验室, 江苏 南京 210009) 摘要: 中药药代动力学研究是中药现代化研究链上一个不可分割的重要组成部分，在创新中药及现代复方中 药研发中发挥着重要作用，但目前尚缺乏符合中药自身特征的药代动力学研究与评价技术体系，对于中药药代 动力学学科关键科学问题的认识不够清晰。本文扼要概述了本课题组近年来在中药多组分整合药代动力学、体 内 物质组分析、基于机制的方剂组分配伍规律研究及中药有效成分药代动力学研究进展，并试从面向中药现 代化研究实际需求的角度，分析和讨论了中药药代动力学学科的关键科学问题，以期能够起到 “抛砖引玉”的 作用，共同促进我国中药药代动力学研究水平的提高。 关键词: 中药药代动力学; 多组分多靶点; 研究方法与体系 中图分类号: R285.6 文献标识码:A 文章编号: 0513-4870 (2009) 03-0270-06 Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets * HAO Hai-ping, ZHENG Chao-nan, WANG Guang-ji (Key Lab of Drug M etabolism and Pharmacokinetics, China Pharmaceutical University, Nanj ing 210009, China) Abstract: The pharmacokinetic research of traditional Chinese medicines (TMC) is an inalienable part of the chain of TCM modernization and plays an important role in the TCM novel drug development. However, the researching method and system that is consistent with the specific characteristics of TCM, i.e., multiple- components and targets, is still lacking. Furthermore, the current understanding of the critical scientific questions of TCM pharmacokinetics remains still unclear. This review makes a brief summary of our recent developments on the pharmacokinetic exploration of TCMs, mainly including integral pharmacokinetic study of multiple components, herbalome analysis both in vitro and in viv