质子泵抑制剂干预疗程对非甾体类抗炎药溃疡性再出血的影响.pdfVIP

1769 质子泵抑制剂干预疗程对非甾体类抗炎药 溃疡性再出血的影响 陈会松叶国良程德希盛红谢韵琴 摘要 目的：探讨质子泵抑制荆(protonpump anti．inflammatory drugs，NSAIDs)所致消化性溃疡并出血的治疗作用。方法：将我院门诊及住院确诊因服用非甾体 类抗炎药致上消化道出血的118例患者分为3组：A组服用PPI2—3个月后停服．B组应用PPI12个月并拟继 续应用．C组同时应用PPI及胃黏膜保护剂。疗程同B组。比较3组患者1年内上消化道再出血发生率的高低。结 生率。长期干预治疗(疗程1年)可明显减少非甾体类抗炎药所致上消化道出血及再出血的发生率。是否合用胃 黏膜保护剂对上消化道再出血发生率无明显影响。 关键词溃疡； 非甾体类抗炎药；再出血； 质子泵抑制荆； 干预疗程 EffectsofdifferentcOlllrs档of inhibitoron tract innon· gastrointestinalrehaemorrhagta protonpump upper steroidal inducedulcerCHEN anti·inflammatory De—xi，SHENG drugs Hui·song，YEGuo—liang，CHENG Hong， XIE No．J Yun—qin．DepartmentofDigestion，XiangshanCountypeople’8Hospital，M，l妒o315700，China To the effectsofdifferentcoursesof 【Abstract】Objectivethempeufic proton inhibitor(PPI)on explore pump tract innon·steroidal uleer．Methods uppergastrointestinalrehaemorrhagia anti-inflammatorydrugs(NSAIDs)induced 11 with NSAIDswere toreceivePPIfor2-3 8 tract induced patientsuppergastrointestinalhemorrhageby assigned receivePPIfor12 receivePPI additivefor12 A)，or months(groupB)，or plusmueopmtecfive months(group incidenceof in tractinone the3 were C)．The months(group rehaemorrhagiauppergastrointestinalyearamonggroups