内皮特异和富含miRNAs对血管功能的影响.pdfVIP

临床与病理杂志 2014, 34(6) J Clin Path ol R e s 773 DOI:10.11714/j.issn.2095-6959.2014.06.027 /articles/794 内皮特异和富含miRNAs对血管功能的影响 吴艳，杨芝春，彭军 (中南大学药学院药理学系，长沙 410078) [摘　要] MicroRNAs (miRNAs) 是广泛存在于真核生物中的一组不编码蛋白的小分子RNA ，由含茎环结构的 miRNA前体经核糖核酸酶 (Dicer)加工后形成。在真核生物中，miRNAs具有组织特异性和时序性， 只在特定的组织和发育阶段表达，在细胞的分化、生长和凋亡过程中发挥广泛的作用。大量研究 表明内皮特异和内皮富含的miRNAs 对血管功能的调节有重要作用，如内皮细胞特异性miR-126 在 维持血管内皮完整性、炎症反应以及血管新生过程中均有显著作用；内皮富含的miR-221/222 、 miR-21 等参与炎症反应、血管新生、内皮衰老等功能的调节。 [关键词] 内皮特异miRNAs ；内皮富含的miRNAs ；血管功能 Effects of endothelial-specific and endothelial-enriched miRNAs on vascular function WU Yan, YANG Zhichun, PENG Jun (Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha 410078, China) Abstract miRNAs, widely presenting in eukaryotes, are a group of non-coding small RNAs generated from hairpin miRNA precursors (pre-miRNAs) by Rnase-Dicer. It has been demonstrated that miRNAs possess the characteristics of tissue specificity and sequential expression and only express in particular organs at stages of special developments. miRNAs play an essential role in cell differentiation, proliferation and apoptosis. Numerous studies show that endothelial-specific and endothelial-enriched miRNAs exert effects on vascular function. For example, endothelial- specific miR-126 plays a vital role in inflammation, angiogenesis, as well as endothelial integrity, while endothelial- enriched miR-221/222 and miR-21 participate in regulation of in