莫西沙星心脏安全性文献计量分析.pdfVIP

  莫西沙星心脏安全性文献计量分析 唐铭婧，白楠，王冬，梅和坤，曹江，江学维，朱坤宁，王睿，王瑾* （解放军总医院药物临床研究中心，北京 100853 ） 【摘 要】 目的：对喹诺酮类药物莫西沙星引起心脏安全性国内外文献进行计量分析， 以期提示临床注意心脏不良反应。 方法：利用PubMed 、Embase 、CNKI收集1999-2013 年的文献，分析莫西沙星引起心脏QT 间期延长的不良反应发生的文献发表年限分布、文 献类型、相关文献被引频次、发表文献的作者和期刊以及论著研文的内容。 结果：国内 外莫西沙星心脏安全性相关文献总数为 240 篇，中文 102篇，英文 138篇；自2000年发 表第一篇后2010年至今成为国内外研究莫西沙星心脏安全性的热潮时期；莫西沙星文献发 表数量呈逐年增长的趋势，莫西沙星的TQT试验及meta分析日益增多；国内发表的高证据 级别研究文献少于且晚于国外，国内主要为临床试验案例研究和不良反应，国外主要为随 机对照试验和TQT研究。结论：莫西沙星的心脏安全正在被受到广泛地关注，研究内容也 越加的深入。 关键词：莫西沙星；文献研究；计量分析 Bibliometric Analysis of Cardiac safety of moxifloxacin TANG Ming-jing, BAI Nan, WANG Dong, MEI He-kun, CAO Jiang, JIANG Xue-wei, ZHU Kun-ning, WANG Rui, WANG Jin* (Medicine Clinical Research Center，PLA General Hospital, Beijing 100853, China) 【Abstract 】 Objective: To investigate the current status and focus of both domestic and foreign literature that cardiac safety caused by moxifloxacin ,then to prompt clinical attention of cardiac adverse reactions of moxifloxacin and provide information for clinical treatment of moxifloxacin. Methods: All publications about Cardiac safety of moxifloxacin were collected from PubMed, Embase, CNKI in 1999-2013. Statistical analysis was performed according to the publication year, basic or clinical study, publication types. Results: Domestic and foreign literature of moxifloxacin is a total of 240 pages, including Chinese literature 102 page, English literature 138 page; The publications concerning Cardiotoxic of moxifloxacin grew steadily year by year. ICH-E14 recommend the use of moxifloxacin as a positive control of new drugs TQT study, so moxifloxacin TQT trials and meta-analysis is increased from 2005;The major domestic publication type focused