帕珠沙星与头孢哌酮-舒巴坦联用对金葡菌等多重耐药菌体外抗菌效果的研究.pdfVIP

帕珠沙星与头孢哌酮／舒巴坦联用对金葡菌等多重耐药菌体外抗菌效果的研究 娄晟+，朱君荣，史益星(南京医科大学附属南京第一医院药剂科，南京市210006) 中图分类号 R978．1；R969．3文献标识码 A 文章编号 1001—0408(2008)11—0830—03 摘要 目的：评价帕珠沙星与头孢哌酮／舒巴坦对临床分离的90株常见致病茵的体外联合抗茵效应。方法：采用棋盘设计法，微 FIC2为0。结论：帕珠沙星与头孢哌酮／舒巴坦联合应用，对90株医源性常见致病茵抗茵作用增强，体外抗茵作用以协同和相加 作用为主，无拮抗效应。 关键词 帕珠沙星；头孢哌酮／舒巴坦；联合用药；FIC InVitroAntibacterialofPazufloxacinCombinedwith Activity Cefoperazone／SulbactamAgainst ResistantBacteria LOU to First Affiliated Sheng，ZHUJun—rong，SHIYi—xing(Dept．ofPharmacy，NanjingHospital Nanjing Medical University，Nanjing210006，China) ABSTRACTOBJECTIVE：TovaluatetheantibioticeffectsinvitroofPazufloxacincombinedwith 90common bacteriafrom infection．METHODS：Thewas checker- against pathogenic hospitalacquired by protocoldesigned boardmethod．TheMICoftwoantibioticsaloneorincombination90 30 aureus，30 againststrains(includingstaphylococcus Pseudomonas Escherichiacolis，30 detectedbrothdilutionmethodandtheFICindexwascalculatedac． aeruginosas)wereby tOMICvalues：RESULTS：TheMICofPazufloxacincombinedwith 90strainswas cording cefoperazone／sulbactamagainst reduced oftheFICindexmaintainedatlessthan 2were60．7％～ significantly．Thepercentage 0．5，0．5--1，1～2，above 80．0％，20．0％～33．3％，3．3％～6．6％，and antibioticofPazufloxacincom- 0％respectively．CONCLUSl0N：Theactivity binedwith 90common strains against from infectionwasenhanced cefoperazone／sulbactamiatrogenic hospitalacquired signif-