靶向性抗菌肽研究概况.pdfVIP

靶向性抗菌肽研究概况 刁昱文，赵红蕾，冯新，韩文瑜，雷连成，孙长江，杜涛峰，刘珊珊 (吉林大学畜牧兽医学院，长春130062) 摘要：很多研究表明抗菌肽对细菌和肿瘤细胞有着很强的杀灭作用．细胞表面的正负电荷吸引是抗菌肽与细菌和肿瘤 细胞的主要作用机制之一，也有研究表明抗菌肽可能在细菌和肿瘤细胞表面有特异性的结合作用位点．然而，靶向性抗菌肤 的设计和应用可以特异靶向性杀灭病原茵而保护正常有益茵群。对抗肿瘤特异靶向性抗菌肽的研究，可以提高肿瘤治疗的特 异性和杀伤能力． 关键词：靶向性抗菌肤；抗细菌多肤；抗肿瘤多肽 GeneralReviewinthe onthe Antimicrobial Study Targeted Peptides DIAO Yu．wenl，ZHAOHong．1eil，FENGYOnl，HANWen．yul+，LEI Lian—chen91，SUNChang-jian91，DU Shan-shanl Tao—fen91，LIU ofAnimalScienceand (College VeterinaryMedicine，Jilin University,Changchun130062，China) shown Abstract：Anumberofstudieshave thatsomeoftheantimicrobial abroad of growing peptides(AMPs)，exhibitspectrum bacteriaandcancercell．Theelectrostaticattractionbetweenthe ofbacterial cytotoxicactivityagainst negativelychargedcomponents and andthe isbelievedto a roleinthe and cancelcells selective of positivelycharged氏K疆s playmajor strongbinding disruption bacterialandcancl．’rcell callbe tuned theattachof membranes，respectively．However,AMPactivity specificallythrough molecules， the antimicrobialto the nornmlflorawhilst the ofinfectivebacteria peptidespreserve treating specificallytargeted protective majority inthe AMeswould facilitatethe ofmoreand selectiveAMeswith community．Cancer study design highly cell—targeting greatly