丛集性头痛患者静息态脑功能连接研究.pdfVIP

丛集性头痛患者的静息态脑功能连接研究 AlteredResting-stateFunctionalConnectivityoftheHypothalamusin ClusterHeadachePatients 邱恩超1于生元2*王岩3马林3刘若卓1董钊1姜磊1田丽霞4邹智彤3徐贤3 1解放军总医院第一附属医院神经内科，北京1000372解放军总医院神经内科 3放射诊断科，北 京1008534北京交通大学，北京100044 目的：利用静息态fMRI研究丛集性头痛患者与下丘脑发生功能连接的脑区变化，以进一步了解丛集性 头痛的疼痛发生机制。 方法：12例右侧丛集性头痛患者和12例正常对照，均为男性，右利手。患者头痛自发发作期间、头痛 缓解期，以及正常对照分别进行fMRI扫描。对采集的fMRI数据利用SPM5软件包进行功能连接分析，自发 发作期与缓解期之间统计分析采用配对t检验，头痛自发发作期间与正常对照之间统计分析采用成组t检验 （P＜ 0.05，蒙特卡罗模拟校正）。选取与下丘脑功能连接增高的脑区为感兴趣区，将每个个体的平均功能连 接值做成散点图，取一界限值，计算得到鉴别头痛自发发作期与缓解期、头痛自发发作期与正常对照的敏感 度和特异度。 AlteredResting-stateFunctionalConnectivityoftheHypothalamusinCluster HeadachePatients EnchaoQiu1ShengyuanYu2YanWang3LinMa3RuozhuoLiu1ZhaoDong1LeiJiang1LixiaTian4Zhitong Zou3XianXu3 1DepartmentofNeurology,TheFirstAffiliatedHospitalofChinesePLAGeneralHospital,Beijing,100037 2DepartmentofNeurology,3DepartmentofRaidiology,ChinesePLAGeneralHospital,Beijing100853;4Schoolof ComputerandInformationTechnology,BeijingJiaotongUniversity,Beijing100044 Objective:Toassessthechangesinbrainfunctionalconnectivityofthehypothalamusinpatientswith spontaneousclusterheadacheusingresting-statefunctionalmagneticresonanceimaging(fMRI). Methods:ThefMRIscanswereobtainedoftwelvemaleclusterheadachepatientswithspontaneousright-sided headacheattacksduring ‘inattack’and ‘outofattack’periodsandtwelveage-andsex-matchednormalcontrols.The functionaldatawereanalyzedtodetectthebrainregionsthathavealteredfunctionalconnectivitywiththeright hypothalamusbythefunctionalconnectivitymethodusingSPM5software.Thesebrainregionswerefurther analyzedaboutsensitivityandspecificitytodistinguishtheclusterheadachepatientsduring ‘inattack’periodfrom ‘outofattack’ period,andclusterheadachepatientsfromnormalcontrols.