中药制剂及给药系统的物质组释放_溶出动力学原理_陈立兵.pdfVIP

39 2008 中草药 Chinese Traditional and Herbal Drugs 64 1 / X 1 2* 3 1 陈立兵, 张继稳 , 顾景凯, 葛卫红 ( 1. , 3 10053; 2. , 20 1203; 3. , 130021) : / , , , : ; ; / : R283. 3: A : 0253- 2670( 2008) 05- 0641- 04 Principles of chemomic release/ dissolution kinetics for Chinese materia medica in conventional dosage forms or drug delivery systems 1 2 3 1 CHEN Li-bing , ZHANG i-w en , GU ing-kai , GE Wei-hong ( 1. College of Phar maceutical Science, Zhejiang Univ ersity of T radit ional Chinese M edicine , Hangzhou 310053, China 2. Genter for Drug Delivery Sy st em, Shanghai Inst itute of M ater ia M edica, Chinese A cademy of Sciences, Shanghai 201203, China; 3. Research Center for Drug M etabolism, ilin Univer sity , Chang chun 13002 1, China) : , , / Abstract T he concepts theorems and principles of the chemom ic release dissolution kinetics for Chinese materia medica ( CM M ) w er e graphically elucidated by the intro duction of the research background, evaluation pr inciples and m ethods, and the pr im ary evaluatio n process of the new m ethod. A vivid presentatio n should be able to facilitate the com pr ehensio n of the ter ms and concepts of the chem ome , , / , . , of CM M the chem omic concentr ation chemom ic release dissolution prof iles etc to further pr omote the application of the new theory in desig n and ev aluation of CMM in drug delivery systems, and to renew the co nventio nal do sage