肺炎支原体感染患儿血清腺苷脱氨酶及C反应蛋白的变化分析.pdfVIP

· l72 检验医学2011年3月第26卷第 3期 LaboratoryMedicine，March2011，Vol26．No3 文章编号：1673—8640(2011)03-0172-03 中图分类号：Q554 文献标识码 ：A 肺炎支原体感染患儿血清腺苷脱氨酶及 C反应蛋 白的变化分析 晏 峰， 丁友法 (温州医学院附属第六医院检验科 ，浙江 丽水 323000) 摘要 ：目的 探讨肺炎支原体 (MP)感染患儿血清腺苷脱氨酶 (ADA)活性与C反应蛋 白(CRP)水平的变 化，以评估其细胞免疫状态，并探讨其临床意义。方法 选取325例呼吸道感染患儿，将94例血清MP—IgM阳性 患儿作为肺炎支原体感染组(阳性组)，将231例阴性患儿作为非支原体感染组 (阴性组)，此外选取32名正常 体检儿童作为对照组，检测3组ADA活性及CRP水平。结果 阳性组患儿的ADA活性明显高于阴性组和对照 组(P0．001)，阴性组和对照组间差异无统计学意义 (P0．05)。阴性组CRP水平明显高于阳性组与对照组 (P0．01)，阳性组与对照组 比较差异无统计学意义 (P0．05)。结论 同时检测患儿血清 ADA和CRP水平可 作为鉴别诊断MP感染的指标，有助于评价疗效。 关键词：腺苷脱氨酶；C反应蛋白；肺炎支原体；儿童 Analysisonthechangeofserum adenosinedeaminaseandC reactiveproteininchildrenwithMycopaisma pneumonia YANFeng，DING 咖 ． (DepartmentofClinicalLaboratory，theSixthAffiliatedHospitalofWenzhou MedicalCollege，ZhefiangLishui323000，China) Abstract：Objective Toinvestigatetheclinicalsignificanceofthechangeofsenlmadenosinedeaminase(ADA) andCreactiveprotein(CRP)levelsinchildrenwithMycoplasmapneumonia(MP)，andevaluatethecellularimmunity state．M ethods 325childrenwithrespiratory infectionwereenrolledinthestudy，andwereclassifiedinto3groups． 94 MP—IgM positive children were performed as positive group，231 children withoutmycoplasma infection were perfomr edasnegativegroup，and32healthychildrenwereenrolledascontrols．Theserum ADA andCRP levelswere measured．Results TheresultsshowedthatADA levelsin positivegroup weresignificantly higherthan those in negativegroupandcontrolgroup(P0．001)．TheADAlevelsinnegativegrouphadnodifferencewiththoseincontrol group(P0．05)．TheCRPlevelsinnegativegroupweresignificantlyhigherthanthoseinpositiveandcontrolgroups (P0．叭)．TheCRPlevelsinpositivegrouphadnodifferencewiththoseincontrolgroup (P|0．05)．Conclusions ThelevelsofADA andCRPmaybethemo