从乙肝疫苗的制备看疫苗纯化技术的发展_张国强.pdfVIP

微生物学杂志 2006 9 26 5 JO UR NAL OF M ICRO BIO LOG Y Sep . 2006 Vo l. 26 N o. 5 59 1 2 张国强, 赵 铠 ( 1. , 100024; 2. , 100024) 疫苗在疾病预防中的地位日益重要, 对疫苗质量的要求也日益提高近年来, 在传 和新型疫苗的 制备中, 应用先进的分离纯化技术是提高疫苗效力降低副反应的有效手段回顾不同时期乙肝疫苗的纯化方 法, 概述当今疫苗纯化技术的应用及发展 乙肝疫苗; 分离纯化 R37 3. 2 A 1005- 702 1( 2006) 05- 0059- 04 Progress on Purification Technique of HBV Vaccine from Its Preparation 1 2 ZHA N G Guo- qiang , ZHA O Kai ( 1. Beij i ng T ian tan Bio-Produ cts Co. L t d . Beij ing 100024; 2. N t l Vaccine Ser um I nst . Beij ing 100024) Abstract As he impor an posi ion of vaccine in disease preven io n day by day, he quali y requiremen of vaccine is also s ressed increasingly. R ecen ly , he u se of advanced pur if ica ion echnolog y in he prepara ion process of bo h r adi ional and new ype vaccines is an eff ec ive means in improv ing eff icacy and reducing adverse reac ion of he vac- cines. Pur if ica ion me hods of HBV vaccine during diff eren periods are r eview ed in his paper, and he applica ion and developmen of he upda e vaccine purif ica ion echnique is summarized. Keywords hepa i is B v accine; purif ica ion echnolo gy H BV , , , -HBs [ 2] DNA , HBsA g , [ 3] , , , , , HBsA g ( CaCl ) , 1 疫苗纯化技术在血源乙肝疫苗生 2 , 产中的应用 , 50% , 1964 , Blumberg ( 3 000 r/ min) , H BsA g ( H BsA g) , 2 , ,