复方氨酚烷胺片致锥体外系症状1例.pdf

临床 医学 医学信息2014年11月第27卷第 11期（2）MedicalInformation.Nov.2014.Vol.27. No. 11 复方氨酚烷胺片致锥体外系症状1例 张良芬袁赵韵超 渊贵州省贵阳市解放军第44 医院内三科袁贵州 贵阳 550009冤 摘要院复方氨酚烷胺片不良反应为白细胞或血小板减少尧食欲缺乏尧恶心尧呕吐尧皮疹等遥 本文介绍因感冒自行服用复方氨酚烷胺片渊新秀冤2片后外出活动时突发全身不自主抖动袁实属罕 见袁给予停服复方氨酚烷胺片袁加用银杏达莫注射液渊杏丁冤输注5d后症状逐渐减轻袁直至消失遥出现的锥体外系症状副反应可能与特异体质或体敏感性有关遥一旦有该症状袁应立即停用药 物袁避免锥体外系等不良反应的发生遥 关键词院复方氨酚烷胺片曰锥体外系症状 1CasesofExtrapyramidal Symptoms Causedby ComoundParacetamolandAmantadine Hydrochloride Tablets ZHANGLiang-fen,ZHAOYun-chao (Departmentof Medicine,Theforty-fourth Hospitalof PLA,Guiyang550009,Guizhou,China) Abstract：The adverse reactions Comound Paracetamol and Amantadine Hydrochloride Tablets white cell or platelet reduction, lack of appetite, nausea, vomiting, skin rash. In this paper because of coldtotake ComoundParacetamolandAmantadineHydrochlorideTablets (Rookie)2 aftertraveling burst body involuntaryjitter, rare, give off ComoundParacetamolandAmantadineHydrochloride Tablets, plusGinkgoLeafExtractand DipyridamoleInjection (XingDing)infusionof5daysafterthe symptomsgraduallyreduced,untilitdisappeared.Extrapyramidalsideeffectsmayberelated tothe specialphysiqueorbodysensitivity.Oncethe symptoms,shouldimmediatelystopusingthedrug,avoid adversereactionofextrapyramidalsystemetc.. Keywords：Comoundparacetamolandamantadinehydrochloridetablets;Extrapyramidalsymptoms 1临床资料 外系症状为服用复方氨酚烷胺片所致。目前复方氨酚烷胺片引起锥体外系症状的机理不 患者高龄男性，83岁，本次因全身不自主抖动1d入院。既往无锥体外系疾病。患者 清，可能与黑质、纹状体内多巴胺被阻滞有关，正常情况下锥体外系功能依赖于多巴胺含 因感冒自行服用复方氨酚烷胺片（新秀）2片后外出活动时突发全身不自主抖动，抖动时 量，当多巴胺含量不足或其受体被阻滞，使得黑质和纹状体的相互作用功能被解除而出现 感头昏、头晕，头昏主要表现为头部昏沉感，头脑不清爽，自诉抖动发作与转动头颈部关系