尖吻蝮蛇血凝酶用于手术创口止血效果的Meta分析.pdfVIP

尖吻蝮蛇血凝酶用于手术创口止血效果的Meta 分析 石鹤坤，李小玲，林小凤，陈开杰，陈锦珊1 解放军第175 医院/厦门大学附属东南医院药学科（漳州 363000 ）。 摘 要 目的：评价尖吻蝮蛇血凝酶（HCA ）对手术创口止血作用的效果。方法：使 用计算机检索PubMed 、CNKI、CBM、维普和万方等数据库收集采用HCA 治疗手术创口出 血的临床随机对照试验（RCT ），并追溯纳入研究的参考文献。由2 位评价者按照纳入与排 除标准独立筛选文献、提取资料和评价质量后，采用RevMan 5.2 软件进行Meta 分析。结果： 最终纳入15 篇文献，共1414 个患者。Meta 分析结果显示：与对照组比较，HCA 可明显减 少患者手术切口创面出血量［MD=-5.53 ，95%CI（-9.00，-2.07 ）］，减少术后引流量［MD=-19.81 ， 95%CI （-26.64，-12.99 ）］，减少切口单位面积出血量［MD=-0.10 ，95%CI （-0.14，-0.07 ）］， -74.85，-26.49 ）］，两组比较差异均有统计学意义。结 缩短止血时间［MD=-50.67，95%CI （ 论：术前给予尖吻蝮蛇血凝酶能明显减少手术患者切口创面出血量、术后引流量和切口单位 面积出血量，并缩短止血时间。 关键词 尖吻蝮蛇血凝酶；止血；Meta 分析；随机对照试验 Effects of Hemocoagulase agkistrodon for hemostasis in surgical tresis vulnus: A Meta-Analysis Shi Hekun, Li Xiaoling, Lin Xiaofeng, Chen Kaijei, Chen Jinsan* Department of Pharmacy, 175 Hospital of PLA/ Affiliated Southeast Hospital of Xiamen University, Zhangzhou, Fujian, 363000 China ABSTRACT Objective: To review the effects of hemocoagulase agkistrodon (HCA) for hemostasis in surgical tresis vulnus. Methods: Databases including PubMed, CNKI, CBM, VIP and Wanfang were searched electronically to collect literature published. Randomized controlled trials(RCTs) were identified about HCA for hemostasis in surgical tresis vulnus. References of the included studies were also retrieved. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assess the quality of the included studies. Then meta-analysis was performed using RevMan 5.2 software. Results: Fifteen trials involved 1414 patients were included. The results of meta-analysis indicated that, using HCA for hemorrhagic volume in surgical tresis vulnus(MD=-5.53 ，95%CI -9.00 to -2.07)，drainage volume after the operation(MD