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structure-activity of type I interferons外文翻译.pdf

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Biotherapy 10: 59-86, 1997. 59 ~) 1997KluwerAcademicPublishers. Printedin theNetherlands. Structure-activity of type I interferons G i u s e p p e C. V i s c o m i Dept. ofBiotechnology and Immunology, Alfa Wassermann,Bologna, Italy Accepted in final form23 July 1996 Key words: interferon alpha, interferon beta, interferon omega, structure-activity Abstract Type I IFNs consitute a family of proteins exhibiting high homology in primary, secondary, and tertiary structures. They interact with the same receptor and transmit signals to cellular nucleus through a similar mechanism, eliciting roughly homogeneous biological activity. Nevertheless, the members of that family, IFNa species, IFNfl and IFN~a, due to local differences in the structure sometime show distinct properties. From the reported data it results that even minute changes or differences in the primary sequences could be responsible for a significant variety of biological actions, thus inducing to the hypothesis that Type I IFNs, rather than to be the result of a redundant replication during the evolution, play definite roles in the defense of living organisms to foreign agents. Abbreviations: Ab-IFNa - antibodies to alpha interferon; Ab-IFNfl - antibodies to beta interferon; Ala - alanine; Arg - arginine; Asp - aspartic acid; Bo - bovine; Cys - cysteine; Gin - glutamine; Glu - glutamic acid; Gly - glycine; His - histidine; Hu - human; IFN - interferon; IFNa - alpha interferon; IFNfl - beta interferon; IFN7 - gamma interferon; IFN~o - omega interferon; IFN7- - tau interferon; IFNA - gene of alpha interferon; IFNB - gene of