《Mechanism of T cell regulation by microRNAs.》.pdf

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2015-12-02 发布于河南
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《Mechanism of T cell regulation by microRNAs.》.pdf

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CancerBiolMed2013；10：131·137．doi：10．7497／j．issn．2095-3941．2013．03．002 REVIEW Mechanism ofTcellregulationbymicroRNAs JuanLiu，Chang—PingWu，Bin—FengLu，Jing—TingJiang DepartmentofTumorBiologicalTreatment，TheThirdAffiliatedHospitalofSoochow University,Changzhou213003，China DepartmentofImmunology,UniversityofPittsburghSchoolofMedicine，Pittsburgh，PA 15261，USA MicroRNAs(miRNAs)aresmallJnon-codingsingle-strandedRNAsthatcanmodulatetargetgeneexpressionatpost— transcriptionallevelandparticipateincellproliferationJdifferentiation，nadapoptosis．Tcellshaveimportantfunctionsin acquiredimmuneresponse；miRNAsregulatethisimmuneresponsebytargetingthemRNAsofgenesinvolvedinTcell development,proliferation,differentiation,andufnction．Forinstance,miR-181familymembersfunctioninprogression bytargetingBcl2andCD69，amongothers．MiR-17tomiR-92clustersfunctionbybindingtoCREBIJPTEN,andBim． ConsideringthatthesuppressionofTceU-mediatedimmuneresponsesagainsttumorcellsisinvolvedincancerprogression, weshouldinvestigatethemechna ismbywhichmiRNAregulatesTcellstodevelopnewapproachesforcancertreatment． M icroRNA；Tcell；geneexpression Introduction RNAs(1ncRNAs)．SimilartomRNAJlncRNAsaremorethan 200nucleotides(nt)inlengthwitha5’methylcapnadapolyA Cancerprogressionisassociatedwithmanygenemutations tail．However,smallRNAsarelessthan200nt；thesesmall andabnormalgeneexpressions．Asaresult,tumor—specificand RNAsincludetRNAJrRNAJsnRNA，siRNA，andmicroRNA tumor—associatedantigens，whichcanstimulateT cellimmune (miRNA)．MiRNAsareanimportantclassofendogenously responses