大肠癌中肿瘤侵袭相关蛋白的表达及其临床意义.pdf

大肠癌中肿瘤侵袭相关蛋白的表达及其临床意义.pdf

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MYHlMYHlMYHlMYHlMYHlReal23timel1 MYHlB2 werewaswaswerewithABSTRACTMYHllMMP-9MYHMMP.9MYHlMYHmatchedBDukesnoProteinsThehasTheThehadDukesTheTheTheaTumorColorectalnormalnormalnormalnormalone3RelatedCancer1anda-actinandcancercancercancercancercancercancer.ofofofofofofofandand2ofof66.7%ofofandfurtherfeaturestoofclinicaldetectcorrelationcolorectal3correlationcorrelationandandfeatures.fromthisthetissuethethatthecommondetectedcolorectalclinicalcorrelationthetumors.thetissuestissuesthattissuethanthattissuethanthatthethetissuetumortissuecancerthansamesameInleveslevelsisincreasesinininininlevellevellesslevellevel111InvasioninindicatedinininincreasedinlVlMP.9∽0.0 werewithMYHMMP一9MYHlmetastasis4betweennoaTheThehasreducesnodeO‘一actina.actinandcancerof2colorectal3correlationandtissues.tissue.correlationthesameininlevels11 11.1 MYHl1.21.3 ARBufferedRotor-GeneRG-3CORBETTRESECH0022.12.1.1 AArTAMMYHlGreenGreenGreenRealRealRealSYBR8s4009MdNTPSYBR2.2.25x750010time—PCRtimetimetime110m MYHlMYHl21 MYHlMYHlMYHl43 withNANMYHlMYHl42DCaoo2Positive33CarelativeCCRCnormal555ofof1113lllevelin·MYHll NDDl^■408060Cofct-actin.14120■O100 withN0Ca20CRCnormalofofOPN1510in…■…OPNrelativelevel NMMP一9MMP一9ooCarelative16100inCRClevel MYHlMYHlMYH9o48765432100.00一9caneercancer317000O0O0000tissue.tissue.33.3%oflincolorectalincolorectalincolorectal0.51.01.52.0Relative NMYHlmRNADDressCd4OoZ2.S2Relativenormalnormal0and3colcorectalltissuetissue.colorectalexDresslon18tumor1llinlevel1 withwithwithwithAUCaseNoMalemetastasismetastasismetastasisMYHDucksPatients’CharacteristicsFemaleGenderTumorno.ofColonRectumnodeOO.6484OTableTable2nodeCorrelationCorrelation900.42900.3470.3880cancer24ofoffeaturesfeaturescolorectalct·actioncolorecta!cancersiteInfiltration19112111141191111211310linin11 withwithNometastasismetastasisMMP-9DucksPatients’P-Valuenodenodeno.ofCharacteristicsTable4208Correlation0.38822canceroffeaturescolorectall111011131in MYHllMYHMMP.9rrrrP—valueCo.elationOPNO.221O.071O.74OPNO.114at21a-actina-ac

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