a single-point mutation enhances dual functionality of a scorpion toxin：一个单点突变增强了蝎子毒素的双重功能.pdfVIP

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a single-point mutation enhances dual functionality of a scorpion toxin：一个单点突变增强了蝎子毒素的双重功能.pdf

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a single-point mutation enhances dual functionality of a scorpion toxin：一个单点突变增强了蝎子毒素的双重功能

Comparative Biochemistry and Physiology, Part C 179 (2016) 72–78 Contents lists available at ScienceDirect Comparative Biochemistry and Physiology, Part C journal homepage: www. /locate/cbpc A single-point mutation enhances dual functionality of a scorpion toxin Xueli Wang, Bin Gao, Shunyi Zhu ⁎ Group of Peptide Biology and Evolution, State Key Laboratory of Integrated Management of Pest Insects Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, 100101 Beijing, China a r t i c l e i n f o a b s t r a c t Article history: Scorpion venom represents a tremendous, hitherto partially explored peptide library that has been proven to be Received 18 June 2015 useful not only for understanding ion channels but also for drug design. MeuTXKα3 is a functionally unknown Received in revised form 24 August 2015 scorpion toxin-like peptide. Here we describe new transcripts of this gene arising from alternative Accepted 1 September 2015 polyadenylation and its biological function as well as a mutant with a single-point substitution at site 30. Available online 7 September 2015 Native-like MeuTXKα3 and its mutant were produced in Escherichia coli and their toxic function against Drosophila Shaker K+ channel and its mammalian counterparts (rK 1.1–rK 1.3) were assayed by two-electrode Keywords: