左旋丁基苯酞抗脑缺血和抗老年痴呆 的药理作用及机制研究.docVIP

左旋丁基苯酞抗脑缺血和抗老年痴呆 的药理作用及机制研究 　　摘要：目的：研究左旋丁基苯酞抗脑缺血和抗老年痴呆的药理作用及机制。方法：根据老年痴呆的主要临床表现，设计四项实验分别研究左旋丁基苯酞对改善脑缺血后大鼠神经功能损伤的作用、对减小大鼠脑梗塞体积的作用，血栓抑制率及血栓形成后大鼠存活率的影响以及认知记忆功能改善的作用。结果：观察组应用L-NBP后神经行为显著改善，P0.01，具有统计学显著性差异；用药后观察组神经行为评分显著优于对照组，P0.01；观察组脑梗塞体积占比显著低于对照组，P0.01；观察组血栓抑制率与存活率均显著优于对照组，P0.01；训练5d后观察组潜服时间显著短于对照组，P0.01；移除安全岛后观察组在原安全岛区域停留时间显著长于对照组，P0.01。结论：左旋丁基苯酞可改善脑缺血局部的血流灌注，对自由基形成与炎性反应产生抑制，通过提升胆碱乙酞基转移酶活性起到减少神经细胞凋亡的作用从而对因缺血缺氧导致的神经细胞受损进行保护，因此可有效改善老年痴呆的病理与行为。 　　关键词：老年痴呆 左旋丁基苯酞 脑缺血 　　Left-handed butyl phthalide against cerebral ischemia and the pharmacological activities and mechanisms of alzheimers research 　　Huang Renfei 　　The second peoples hospital of anhui hefei 230011 in anhui province 　　 abstract ： objective: to study the sinistral butyl phthalide against cerebral ischemia and the pharmacological activities and mechanisms of alzheimers disease. Methods: according to the main clinical symptoms of dementia, design four experimental research sinistral butyl phthalide respectively to improve the neural function damage after cerebral ischemia rats, to reduce the volume of infarction rats thrombosis inhibition rate and the influence of thrombosis after rat survival rate and improve the role of cognitive memory function. Results: the observation group after application of L - NBP neural behavior improved significantly, P 0.01, statistically significant difference; Use neurobehavioral scores significantly better than control group after group, P 0.01; Observation group of cerebral infarction volume percentage significantly lower than the control group, P 0.01; Observation group thrombosis inhibition rate and survival rate were significantly better than the control group, P 0.01; Training group after 5 d dive suit time significantly shorter than the control group, P 0.01; After removing the safety island group in the area of safety island stay time was significantly longer than the control group, P 0.01). Conclusion: levorotatory butyl phthalide can improve the local blo