活化转录因子3、4和ki―67在皮肤鳞癌中的表达意义.docVIP

活化转录因子3、4和ki―67在皮肤鳞癌中的表达意义 　　?基础研究? ?论著? 　　活化转录因子3、4和ki-67在皮肤鳞癌中的表达意义 　　李 春，周为军，宋朝辉，李朝阳，余 萍，曾学文，郭智龙 　　（新疆自治区人民医院整形外科 新疆 乌鲁木齐 830000） 　　[摘要]目的：探讨活化转录因子3、4和ki-67在皮肤鳞癌和基底细胞癌中的表达及其临床意义。方法：从笔者所在医院病理科储存的蜡块中随机选择96例皮肤鳞癌和118例基底细胞癌标本，采用免疫组织化学方法检测组织中活化转录因子3、4和ki-67的表达，分析其表达意义。结果：活化转录因子3、4在皮肤鳞癌中的表达较基底细胞癌高，差异有统计学意义（P值分别为0.003和0.001）。Ki-67在两种皮肤癌中的表达无显著差异（P值为0.718）。ATF3、4的表达强度和皮肤鳞癌分化程度成正相关，即分化程度低越低，表达强度越高（r=0.395 P=0.000和r=0.303 P=0.001）。结论：活化转录因子3、4可以作为鉴别皮肤鳞癌和基底细胞癌可靠的蛋白标记物和皮肤鳞癌恶性程度及预后的判断指标。 　　[关键词]皮肤鳞癌；基底细胞癌；免疫组化；活化转录因子3、4；ki-67 　　[中图分类号]R730.261 [文献标志码]A [文章编号]1008-6455（2015）12-0040-04 　　The expression meaning of activating transcription factor 3，activating transcription factor 4 and ki-67 in skin squamous cell carcinoma 　　LI Chun，ZHOU Wei-jun，SONG Zhao-hui，LI Zhao-yang，YU Ping，ZENG Xue-wen，GUO Zhi-long 　　（Department of Plastic Surgery，Xinjiang Autonomous Region People’s Hospital， Urumqi 830000，Xinjiang，China） 　　Abstract： Objective To discuss the expression of activating transcription factor 3，activating transcription factor 4（ATF3，4）and ki-67 in skin squamous carcinomas and basal cell carcinomas and their clinical significances. Methods Using immunohistochemical method to detect ATF3，4 and ki-67 expression in 96 cases of skin squamous carcinoma and 118 cases of basal cell carcinoma tissues，which were randomly selected from the hospital preserved in pathology department，then analysis the meaning of expression. Results ATF3，4 in skin squamous carcinomas is higher than that in basal cell carcinomas，the differences were statistically significant（P=0.003 and 0.001， respectively），but there was no difference for ki-67（P=0.718）.Positive correlation could be found between ATF3，4 expression strength and skin squamous cell carcinoma differentiation（r=0.395，P=0.000；r=0.303，P=0.001，respectively）. Conclusion ATF3，4 may be used as the reliable differential protein markers between skin squamous cell carcinoma and basal cell carcinoma，and they be seen as malignant degree and prog