RNA干涉技术解析.pptVIP

This years (2006) Nobel Prize in Physiology or Medicine is shared by Professor Andrew Z. Fire at Stanford University, California, USA, and Professor Craig C. Mello at the University of Massachusetts Medical School in Worcester, USA. They receive the prize for their discovery that double-stranded RNA triggers suppression of gene activity in a homology-dependent manner, a process named RNA interference (RNAi). ? RdRP一般只对靶mRNA起作用，这种在RNAi过程中对靶m RNA 的特异性扩增作用有助于增强RNAi的特异性基因监视功能，每个细胞只需要少量dsRNA却能完全关闭相应基因表达，RNAi过程具有生物催化反应的基本动力学特征。 四、RNAi的生物学意义和应用前景 ? 抑制不重要或有害基因表达对细胞及有机体正常功能的发挥和