112例慢性心力衰竭患者血清NT―proBNP浓度与LVEF水平的临床分析.docVIP

112例慢性心力衰竭患者血清NT―proBNP浓度与LVEF水平的临床分析 　　 [摘要〕：目的 研究慢性心力衰竭（CHF）患者血浆NT-proBNP浓度变化规律及与LVEF相关性。方法 选取2013年5月至2014年5月在我科住院的112例慢性心力衰竭患者，按照纽约心脏病学会（NYHA）心功能分级，采取电化学发光免疫双抗体夹心法定量检测血清NT-proBNP水平，并测定左心室射血分数（LVEF），经抗心力衰竭治疗2周后复测上述指标，进行统计学分析。结果 按NYHA心功能分级的各组患者血桨NT-proBNP的水平差异具有统计学意义， 心功能越低下， NT-proBNP值越高， 而LVEF差异仅在Ⅰ、Ⅲ、Ⅵ级心功能间有统计学意义（P0.05）。经治疗患者心衰症状缓解后，复测NT-proBNP值下降，而LVEF水平升高， 但仅有NT-proBNP的变化有统计学意义。结论 NT-proBNP水平作为慢性心力衰竭患者判断其心功能不全严重程度和疗效是较可靠的指标。 　　【关键词】NT-proBNP;慢性心力衰竭;左心室射血分数（LVEF） 　　中图分类号：R541.61 文献标识码：A 　　Clinical analysis of 112 CHF patients in serum NT-proBNP concentration and LVEF level 　　Hu ren xue（Department of Cardiology， Dantu Peoples Hospital，Zhengjiang，Jiangsu 212100，China） 　　[Abstract] Objective The objective was to study the clinical effect of CHF patients in serum NT-proBNP concentration and LVEF level. Methods 112 cases of CHF patients were selected from our hospital during may 2013 to may 2014. The level of NT-proBNP and left ventricular ejection fraction （LVEF） were determined by echocardiography according to the cardiac grading of New York heart association （NYHA）. The above indexes were retested after two weeks treatment and the statistical analysis was carried out. Results The difference in NT-proBNP had statistical significance according to NYHA cardiac grading. The lower the cardiac function was， the higher the NT-proBNP value was. The difference in LVEF had statistical significance in the range ofⅠ，Ⅲ Ⅵcardiac function（P0.05）. The symptoms of CHF patients were mitigated after treatment. The level of NT-proBNP declined while the level of LVEF went up. Only changes of NT-proBNP had statistical Significance. Conclusions The level of NT-proBNP was a reliable index to judge the cardiac insufficiency degree and curative effect of CHF patients. 　　【Key words〕NT-proBNP; chronic heart failure; left ventricular ejection fraction. 　　慢性心力衰竭是心脏的舒缩张功能障碍引起心排血量不足，从而影响机体组织的代谢发生障碍的临床综合征。神经内分泌的过度激活在心力衰竭的发生、发展中起关键性作用 临床研究发现脑钠肽（BNP）在心功能不全的发生、发展中起重要作用的内分泌激素之一，是由心室