内皮型一氧化氮合酶活性的调节与心血管疾病的研究进展.PDFVIP

中南大学学报（医学版） J Cent South Univ (Med Sci) 2016, 41(6) 632 内皮型一氧化氮合酶活性的调节与心血管疾病的研究进展 刘昭娅，胥茜，唐义信，石瑞正 (中南大学湘雅医院心内科，长沙 410008 ) [摘要] 内皮型一氧化氮合酶(endothelial nitric oxide synthase，eNOS)是合成一氧化氮(nitiric oxide，NO)起主要作用 的酶，eNOS和NO在调节血管壁结构和功能中有重要作用，参与心血管疾病的病理生理过程。eNOS活性的改变除了 常见的磷酸化途径外，还涉及乙酰化、谷胱甘肽化、蛋白质间的相互作用等机制，笔者将简要阐述eNOS的基本结构 和功能、eNOS活性的调节途径及其在心血管疾病中的研究进展。 [关键词] 内皮型一氧化氮合酶；一氧化氮；乙酰化；谷胱甘肽化 Research progress in the regulation of endothelial nitric oxide synthase activity and cardiovascular diseases LIU Zhaoya, XU Qian, TANG Yixin, SHI Ruizheng (Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China) ABSTRACT Endothelial nitric oxide synthase (eNOS) is a major enzyme responsible for nitric oxide (NO) production. Both eNOS and NO play an important role in regulating vessel structure and function through participating in the physiological and pathological process. Generally, the phosphorylation of eNOS has been recognized as a common mechanism for regulation of eNOS function. However, recent studies have demonstrated several other new mechanisms, such as acetylation, S-glutathionylation, and protein–protein interaction. This review highlights the basic structure and functions of eNOS as well as the relationship between regulation of eNOS activity and cardiovascular diseases. KEY WORDS endothelial nitric oxide synthase; nitric oxide; acetylation; S-glutathionylation 收稿日期(Date of reception)：2015-08-14 第一作者(First author)：刘昭娅，Email: 527269518@ 通信作者(Corresponding author)：石瑞正，Email: xysrz2010@ 基金项目(Foundation item)：国家自然科学基金；国家自然科学基金青年基金；国家重点基础研究发展计划 (2014CB542402)；中国博士后基金(2013M542143)。 This work was supported by the National Natural Science Fundation of China and the National Youth Science Foundation of China , the National Basic Reasearch Program of China(2014CB542402), Post-doctor Fund of China (2013M542143). DOI:10.11817/j.issn.1672-7347.2016.06.013 /xbwk/fileup/PDF/201606632.pdf ·RE