1,5alcohol dehydration of glucose measurement in patients with impaired glucose tolerance and diabetes in the value and clinical significance.docVIP

 PAGE \* MERGEFORMAT 12 1,5alcohol dehydration of glucose measurement in patients with impaired glucose tolerance and diabetes in the value and clinical significance Of: Chenjia Jian Ye Yuhui Wen Zhuolian [Abstract] Objective To evaluate the dehydration of glucose, 1,5-alcohols (1,5 AG) as a new indicator in the impaired glucose tolerance (IGT) and diabetes patients and clinical application. Methods All subjects were confirmed by oral glucose tolerance test (OGTT, with pyranose oxidase (PROD) Determination of normal glucose tolerance (NGT, IGT, 2 diabetes mellitus (T2DM subjects serum levels of 1.5 AG. The results normal (30 cases), the level of 1,5 AG (26.76 + -5.28) mg / L, IGT persons (100 cases), (21.43 + -2.52) mg / L, diabetes mellitus (50 cases), (10.69 + -2.72) mg / L, the diabetic group 1,5 AG was significantly lower than the control and IGT group (P lt;0.01), IGT group 1,5 AG lower than the control group (P lt;0.05). Serum 1,5 AG and fasting plasma glucose (FPG, 2 h postprandial glucose (2 hPG, glycosylated hemoglobin (HbA1c showed a significant negative correlation .1,5 AG, FPG and HbA1c, respectively 14 mg / L, 6.2 mmol / L and 6.4% as a diagnostic reference value, the sensitivity was 90.0%, 88.0% 82.0%, specificity was 93.3%, 90.0%, 76.7%. Conclusion Serum 1,5 AG associated with decreased glucose tolerance, IGT and diabetic patients was significantly lower 1,5 AG, Determination of serum 1,5 AG as diabetes diagnosis, screening and monitoring of blood glucose control targets. [Keywords:] glucose 1,5-dehydration alcohol; diabetes; impaired glucose tolerance Serum glucose 1,5-dehydration alcohol (1,5 AG is present in blood in the polyol, the polyol carbohydrate content, second only to glucose (1). In recent years, numerous studies have shown that 1, 5 AG is the second sugar, 24 h quantitative urine glucose, fructosamine, glycated hemoglobin (HbA1c) after another new high sensitivity, promising indicators for monitoring diabetic condition, t